Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities

被引：97

作者：

Nigam, Manisha ^{[1
]}

Mishra, Abhay P. ^{[2
]}

Adhikari-Devkota, Anjana ^{[3
]}

Dirar, Amina Ibrahim ^{[3
]}

Hassan, Md. Mahadi ^{[3
]}

Adhikari, Achyut ^{[4
]}

Belwal, Tarun ^{[5
]}

Devkota, Hari Prasad ^{[3
,6
]}

机构：

[1] HNB Garhwal Univ, Dept Biochem, Srinagar, India

[2] HNB Garhwal Univ, Dept Pharmaceut Chem, Srinagar 246174, Uttarakhand, India

[3] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto, Japan

[4] Tribhuwan Univ, Cent Dept Chem, Kritipur, Nepal

[5] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Zhejiang Key Lab Agrofood Proc, Minist Educ,Key Lab Agroprod Postharvest Handling, Hangzhou, Peoples R China

[6] Kumamoto Univ, Hlth Life Sci Interdisciplinary & Glocal Oriented, Program Leading Grad Sch, Kumamoto, Japan

来源：

PHYTOTHERAPY RESEARCH | 2020年 / 34卷 / 10期

关键词：

Terminalia chebula; Combretaceae; tannins; phenolic acids; antioxidants; bioactivity; INDUCED OXIDATIVE STRESS; INDIAN MEDICINAL-PLANTS; AQUEOUS EXTRACT; HYDROLYZABLE TANNINS; IN-VITRO; ANTIVIRAL ACTIVITIES; ANTIOXIDANT ACTIVITY; AYURVEDIC MEDICINES; ANTIFUNGAL ACTIVITY; WATER EXTRACT;

D O I：

10.1002/ptr.6702

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fruits of Terminalia chebula Retz. (Combretaceae) are widely used as crude drugs in various traditional medicine systems. The aim of this article is to review the available scientific information regarding the traditional uses, bioactive chemical constituents and the pharmacological activities of T. chebula. Numerous researches conducted on T. chebula have confirmed the presence of wide range of the phytochemicals such as flavonoids, tannins, phenolic acids and other bioactive compounds. T. chebula is also widely studied regarding its pharmacological activities such as antioxidant, hepatoprotective, neuroprotective, cytotoxic, antidiabetic, anti-inflammatory activities among others. However, more in vivo and clinical studies for mechanism-based pharmacological evaluation should be conducted in future to provide stronger scientific evidences for their traditional uses.

引用

页码：2518 / 2533

页数：16

共 127 条

[1] Chebulagic Acid Synergizes the Cytotoxicity of Doxorubicin in Human Hepatocellular Carcinoma Through COX-2 Dependant Modulation of MDR-1 [J].