SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma

被引：9

作者：

de Freitas Silva, Brunno Santos ^{[1
]}

Silva, Lorena Rosa ^{[2
]}

de Lima, Kaique Leite ^{[2
]}

Ferreira dos Santos, Amanda Cristina ^{[3
]}

Oliveira, Anna Carolina ^{[3
]}

Dezzen-Gomide, Ana Claudia ^{[4
]}

Batista, Aline Carvalho ^{[5
]}

Yamamoto-Silva, Fernanda Paula ^{[6
]}

机构：

[1] Univ Anapolis, Sch Dent, Dept Oral Diag, Oral Pathol, Anapolis, Go, Brazil

[2] Univ Fed Goias, Sch Dent, Goiania, Go, Brazil

[3] Univ Fed Goias, Sch Dent, Dept Stomatol Sci, Goiania, Go, Brazil

[4] Univ Anapolis, Sch Dent, Anapolis, Go, Brazil

[5] Univ Fed Goias, Sch Dent, Dept Stomatol Sci, Oral Pathol, Goiania, Go, Brazil

[6] Univ Fed Goias, Sch Dent, Dept Stomatol Sci, Oral Radiol, Goiania, Go, Brazil

来源：

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL | 2020年 / 25卷 / 02期

关键词：

Odontogenic keratocyst; Ameloblastoma; Odontogenic tumor; SOX2; BCL-2; HEDGEHOG SIGNALING PATHWAY; CELL-PROLIFERATION; TUMORS; APOPTOSIS; PROTEIN; MARKER; CANCER; TOOTH; GENE; LUNG;

D O I：

10.4317/medoral.23348

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background: The purpose of this experimental study was to compare the immunohistochemical expression of SOX2 and BCL-2 in Odontogenic Keratocyst (OKC) and Ameloblastoma (AB) specimens, and to identify a possible correlation in their expression. Material and Methods: Immunohistochemical analysis was performed to evaluate SOX2 and BCL-2 expression in OKC (n = 20) and AB (n = 20). The immunoexpression was analyzed by a quantitative and qualitative scoring system. The comparison between the immunoexpression of SOX 2 and BCL-2 was assessed by the Mann-Whitney U-test. Spearman's correlation coefficient evaluated the correlation between SOX2 and BCL-2 expressions. Results: SOX2 and BCL-2 expression was observed in all specimens of OKC in the full thickness of the epithelium lining. SOX2 immunostaining was higher in OKC, in comparison with AB samples (P<0.05). BCL-2 immunostaining between OKC and AB was not statistically significant. There was no significant correlation between SOX2 and BCL-2 in OKC and AB specimens. Conclusions: SOX2 and BCL-2 expressions in OKC may suggest their relationship with the biological behavior of this lesion, and the higher expression of SOX2 might be an upstream influence on the Hh signaling pathway.

引用

页码：E283 / E290

页数：8

共 41 条

[1] SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas [J].

Bass, Adam J. ;

Watanabe, Hideo ;

Mermel, Craig H. ;

Yu, Soyoung ;

Perner, Sven ;

Verhaak, Roel G. ;

Kim, So Young ;

Wardwell, Leslie ;

Tamayo, Pablo ;

Gat-Viks, Irit ;

Ramos, Alex H. ;

Woo, Michele S. ;

Weir, Barbara A. ;

Getz, Gad ;

Beroukhim, Rameen ;

O'Kelly, Michael ;

Dutt, Amit ;

Rozenblatt-Rosen, Orit ;

Dziunycz, Piotr ;

Komisarof, Justin ;

Chirieac, Lucian R. ;

LaFargue, Christopher J. ;

Scheble, Veit ;

Wilbertz, Theresia ;

Ma, Changqing ;

Rao, Shilpa ;

Nakagawa, Hiroshi ;

Stairs, Douglas B. ;

Lin, Lin ;

Giordano, Thomas J. ;

Wagner, Patrick ;

Minna, John D. ;

Gazdar, Adi F. ;

Zhu, Chang Qi ;

Brose, Marcia S. ;

Cecconello, Ivan ;

Ribeiro, Ulysses, Jr. ;

Marie, Suely K. ;

Dahl, Olav ;

Shivdasani, Ramesh A. ;

Tsao, Ming-Sound ;

Rubin, Mark A. ;

Wong, Kwok K. ;

Regev, Aviv ;

Hahn, William C. ;

Beer, David G. ;

Rustgi, Anil K. ;

Meyerson, Matthew .

NATURE GENETICS, 2009, 41 (11) :1238-U105

[2] Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1 [J].

Bigelow, RLH ;

Chari, NS ;

Undén, AB ;

Spurgers, KB ;

Lee, SJ ;

Roop, DR ;

Toftgård, R ;

McDonnell, TJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (02) :1197-1205

[3]

Brown Noah A, 2015, Biomark Cancer, V7, P19, DOI 10.4137/BIC.S29329

[4] The sonic hedgehog signaling network in development and neoplasia [J].

Chari, Nikhil S. ;

McDonnell, Timothy J. .

ADVANCES IN ANATOMIC PATHOLOGY, 2007, 14 (05) :344-352

[5] miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors [J].

Diniz, Marina Goncalves ;

Gomes, Carolina Cavalieri ;

de Castro, Wagner Henriques ;

Sena Guimaraes, Andre Luiz ;

Batista De Paula, Alfredo Mauricio ;

Amm, Hope ;

Ren, Chanchung ;

MacDougall, Mary ;

Gomez, Ricardo Santiago .

CELLULAR ONCOLOGY, 2012, 35 (04) :285-291

[6] Ameloblastoma: current etiopathological concepts and management [J].

Effiom, O. A. ;

Ogundana, O. M. ;

Akinshipo, A. O. ;

Akintoye, S. O. .

ORAL DISEASES, 2018, 24 (03) :307-316

[7] Recurrent Copy Number Gain of Transcription Factor SOX2 and Corresponding High Protein Expression in Oral Squamous Cell Carcinoma [J].

Freier, Koija ;

Knoepfle, Karl ;

Flechtenmacher, Christa ;

Pungs, Susanne ;

Devens, Frauke ;

Toedt, Grischa ;

Hofele, Christof ;

Joos, Stefan ;

Lichter, Peter ;

Radwirnmer, Bernhard .

GENES CHROMOSOMES & CANCER, 2010, 49 (01) :9-16

[8] Reclassification of odontogenic keratocyst as tumour. Impact on the odontogenic tumours prevalence [J].

Gaitan-Cepeda, L. A. ;

Quezada-Rivera, D. ;

Tenorio-Rocha, F. ;

Leyva-Huerta, E. R. .

ORAL DISEASES, 2010, 16 (02) :185-187

[9] Molecular alterations in odontogenic keratocysts as potential therapeutic targets [J].

Gomes, Carolina Cavalieri ;

Guimaraes, Leticia Martins ;

Diniz, Marina Goncalves ;

Gomez, Ricardo Santiago .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2017, 46 (10) :877-882

[10] Tumour suppressor properties of miR-15a and its regulatory effects on BCL2 and SOX2 proteins in colorectal carcinomas [J].

Gopalan, Vinod ;

Ebrahimi, Faeza ;

Islam, Farhadul ;

Vider, Jelena ;

Qallandar, Omel Baneen ;

Pillai, Suja ;

Lu, Cu-Tai ;

Lam, Alfred King-yin .

EXPERIMENTAL CELL RESEARCH, 2018, 370 (02) :245-253

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