Rituximab in refractory and non-refractory myasthenia: A retrospective multicenter study

被引：51

作者：

Collongues, Nicolas ^{[1
]}

Casez, Olivier ^{[2
]}

Lacour, Arnaud ^{[3
]}

Tranchant, Christine ^{[1
]}

Vermersch, Patrick ^{[3
]}

de Seze, Jerome ^{[1
]}

Lebrun, Christine ^{[4
]}

机构：

[1] Univ Strasbourg, Dept Neurol, Univ Hosp Hautepierre, F-67000 Strasbourg, France

[2] Univ Grenoble, Dept Neurol, Grenoble, France

[3] Univ Lille Nord France, Dept Neurol, Lille, France

[4] Univ Nice, Dept Neurol, Nice, France

来源：

MUSCLE & NERVE | 2012年 / 46卷 / 05期

关键词：

myasthenia; neuroimmunology; non-refractory form; refractory form; rituximab; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; GRAVIS; STANDARDS;

D O I：

10.1002/mus.23412

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Few data are available about the effect of rituximab (RTX) on refractory (RM) and non-refractory (NRM) myasthenia. Methods: This retrospective multicenter study involved 13 RM and 7 NRM patients treated with sequential RTX infusions over 2 years, on average. RTX was used as a substitute for corticosteroids in NRM patients. Disability was assessed using the annualized relapse rate (ARR) and Myasthenia Gravis Foundation of America (MGFA) scores. Results: RTX induction decreased the ARR from 2.1 to 0.3 (P < 0.001), and lowered MGFA scores from 53b to 4b0 in RM patients, and from 1.9 to 0.1 (P < 0.001) and 4b2b to 3b0 in NRM patients. No side effects were reported in either group, except for 1 case of spondylodiscitis 1 year after the last RTX infusion. Within a year after RTX induction, complete corticosteroid withdrawal was obtained in 7 RM and 4 NRM patients. Conclusions: RTX is efficacious and well-tolerated. Its use allows for dose reduction or withdrawal of corticosteroids. Muscle Nerve, 2012

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页码：687 / 691

页数：5

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