One-Pot Synthesis of Hydroxy Pyrazolo[1,2-a][1,2,4]triazoles and Their Dehydration Using Recyclable Ionic Liquids as Reaction Media

被引：3

作者：

Meena, Kalawati ^{[1
,2
]}

Khurana, Jitender M. ^{[1
]}

Malik, Amita ^{[2
]}

机构：

[1] Univ Delhi, Dept Chem, Delhi 110007, India

[2] Univ Delhi, Dyal Singh Coll, Lodhi Rd, Delhi 110003, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 01期

关键词：

BIOLOGICAL EVALUATION; CONFLUENT APPROACH; DERIVATIVES; PYRAZOLE; EFFICIENT; AGENTS; DBU; INHIBITION; FACILE;

D O I：

10.1002/jhet.3006

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An eco-friendly, simple, and efficient one-pot new procedure has been developed for the synthesis of hydroxy phenylhexahydropyrazolo[1,2-a][1,2,4]triazoles by condensation of 4-phenylurazole, aldehydes, and ethyl/methyl acetoacetate using ionic liquid [bmim]BF4 in presence of l-proline at 80 degrees C. The hydroxy pyrazolo[1,2-a][1,2,4]triazoles could be dehydrated in presence of [bmim]HSO4 to give corresponding phenyltetrahydropyrazolo[1,2-a][1,2,4]triazoles in high yields. High yields, less reaction time, operational simplicity, and recyclability of reaction media are the advantages of this protocol.

引用

页码：83 / 90

页数：8

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