Tamoxifen Induces Rapid, Reversible Atrophy, and Metaplasia in Mouse Stomach

被引：176

作者：

Huh, Won Jae

Khurana, Shradha S.

Geahlen, Jessica H.

Kohli, Kavita

Waller, Rachel A.

Mills, Jason C. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Med, Div Gastroenterol, St Louis, MO 63110 USA

来源：

GASTROENTEROLOGY | 2012年 / 142卷 / 01期

关键词：

BREAST-CANCER; HELICOBACTER-PYLORI; ZYMOGENIC CELLS; PARIETAL-CELLS; MICE; MIST1; RECOMBINATION; PROGENITORS; EXPRESSION; MATURATION;

D O I：

10.1053/j.gastro.2011.09.050

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Tamoxifen, a selective estrogen receptor modulator, is widely used in research and clinically in patients. We find that treatment of normal mice with a single >= 3 mg/20 g body weight dose of tamoxifen leads to apoptosis of >90% of all gastric parietal cells (PCs) and metaplasia of zymogenic chief cells within 3 days. Remarkably, gastric histology returns to nearly normal by 3 weeks. Tamoxifen toxicity occurs by oral and intraperitoneal administration, in both sexes, in multiple strains, and does not depend on estrogen, though acid secretion inhibition is partially protective. Thus, substantial gastric toxicity is a heretofore unappreciated tamoxifen side effect.

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页码：21 / U105

页数：11

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