Unfoldomics of prostate cancer: on the abundance and roles of intrinsically disordered proteins in prostate cancer

被引：7
作者：
Landau, Kevin S. [1 ]
Na, Insung [1 ]
Schenck, Ryan O. [1 ]
Uversky, Vladimir N. [1 ,2 ,3 ]
机构：
[1] Univ S Florida, Dept Mol Med, Morsani Coll Med, Tampa, FL 33612 USA
[2] Univ S Florida, USF Hlth Byrd Alzheimers Res Inst, Morsani Coll Med, Tampa, FL 33612 USA
[3] Russian Acad Sci, Inst Cytol, Lab Struct Dynam Stabil & Folding Prot, St Petersburg, Russia
来源：
ASIAN JOURNAL OF ANDROLOGY | 2016年 / 18卷 / 05期
关键词：
intrinsically disordered proteins; posttranslational modifications; prostate cancer; protein-protein interaction; proteomics; proteome; unfoldome; MOLECULAR INTERACTION DATABASE; NATIVELY UNFOLDED PROTEINS; STRUCTURAL DISORDER; HUB PROTEINS; WEB SERVER; PREDICTION; REGIONS; NETWORK; RECOGNITION; ONTOLOGY;
D O I：
10.4103/1008-682X.184999
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.
引用
收藏
页码：662 / 672
页数：11
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