Five-year clinical outcomes of combined phacoemulsification and trabectome surgery at a single glaucoma center

PurposeTo analyze the 5-year results of trabectome ab interno trabeculectomy of a single glaucoma center.MethodIn this retrospective interventional single-center case series, data of 93 patients undergoing ab interno trabeculotomy between September 2010, and December 2012 were included. Kaplan-Meier analysis was performed using success criteria defined as postoperative intraocular pressure (IOP) 21mmHg, and >20% reduction from preoperative IOP, and no need for further glaucoma surgery. Risk factors for failure were identified using Cox proportional hazards ratio (HR).ResultsThe retention rate for 5-year follow-up was 66%. The cumulative probability of success at 1, 2, 3, 4, and 5years was 82.6%, 76.7%, 73.9%, 72.3%, and 67.5%. Risk factors for failure were lower baseline IOP (HR=0.27, P=0.001), younger age (HR=0.25, P=0.02), and higher central corneal thickness (HR=0.18, P=0.01). Exfoliative glaucoma was associated with a higher success rate (HR=0.39, P=0.02). IOP was decreased significantly from 20.05.6mmHg at baseline to 15.6 +/- 4.6mmHg at 5-year follow-up (P=0.001). The baseline number of glaucoma medications was 1.8 +/- 1.2, which decreased to 1.0 +/- 1.2 medications at 5years.Conclusion p id=Par4 Trabectome surgery was associated with a good long-term efficacy and safety profile in this single-center case series with a high retention rate.