A novel and one-pot method for synthesis of unprecedented 3,3-dimethyl-2-amide indoles under metal-free conditions

被引：7
|
作者：
Liu, Haidong [1 ,3 ,4 ]
Chen, Hao [2 ]
Li, Yuan [2 ]
Lv, Yongfeng [2 ]
Cai, Jin [2 ]
Ji, Min [1 ,3 ,4 ]
机构：
[1] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China
[2] Southeast Univ, Sch Chem & Chem Engn, Nanjing 210096, Jiangsu, Peoples R China
[3] Suzhou Key Lab Biomat & Technol, Suzhou 215123, Peoples R China
[4] Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China
来源：
TETRAHEDRON LETTERS | 2015年 / 56卷 / 18期
关键词：
Indoles; Iodine-promoted reaction; 1,2,3,3-Tetramethyl-3H-indolium iodide; One-pot; Oxidative amidation; BISINDOLE ALKALOIDS; ALPHA-KETOAMIDES; FACILE ACCESS; IODINE; FUNCTIONALIZATION; ACETOPHENONES; CONSTRUCTION; AMIDATION; AMINATION; STRATEGY;
D O I：
10.1016/j.tetlet.2015.03.087
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient method for the synthesis of 3,3-dimethyl-2-amide indoles, employing a I-2/DMSO-promoted oxidative amidation reaction between 1,2,3,3-tetramethyl-3H-indolium iodide and cyclic secondary amines under metal-free conditions has been developed. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2332 / 2335
页数：4
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