Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients

被引：62

作者：

Sukasem, Chonlaphat ^{[1
,2
,3
,4
]}

Chaichan, Chonlawat ^{[1
,2
]}

Nakkrut, Thapanat ^{[5
,6
]}

Satapornpong, Patompong ^{[1
,2
]}

Jaruthamsophon, Kanoot ^{[7
]}

Jantararoungtong, Thawinee ^{[1
,2
]}

Koomdee, Napatrupron ^{[1
,2
]}

Sririttha, Suthida ^{[1
,2
,8
]}

Medhasi, Sadeep ^{[9
]}

Oo-Puthinan, Sarawut ^{[5
]}

Rerkpattanapipat, Ticha ^{[4
,10
]}

Klaewsongkram, Jettanong ^{[4
,11
]}

Rerknimitr, Pawinee ^{[4
,12
]}

Tuchinda, Papapit ^{[4
,13
]}

Chularojanamontri, Leena ^{[4
,13
]}

Tovanabutra, Napatra ^{[4
,14
]}

Puangpetch, Apichaya ^{[1
,2
]}

Aekplakorn, Wichai ^{[15
]}

机构：

[1] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Pathol,Div Pharmacogen & Personalized Med, Bangkok, Thailand

[2] Ramathibodi Hosp, Somdech Phra Debaratana Med Ctr SDMC, Lab Pharmacogen, Bangkok, Thailand

[3] Mahidol Univ, Ramathibodi Hosp, Fac Med, Ramathibodi Multidisciplinary Epilepsy Ctr, Bangkok, Thailand

[4] Thai Severe Cutaneous Adverse Drug React THAI SCA, Bangkok, Thailand

[5] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharm Practice, Phitsanulok, Thailand

[6] Prasat Neurol Inst, Dept Pharm, Bangkok, Thailand

[7] Prince Songkla Univ, Fac Med, Dept Pathol, Hat Yai, Thailand

[8] Mahidol Univ, Fac Pharm, Dept Clin Pharm Practice, Bangkok, Thailand

[9] Mae Fah Luang Univ, Sch Med, Chiang Rai, Thailand

[10] Mahidol Univ, Ramathibodi Hosp, Fac Med, Dept Med,Div Allergy Immunol & Rheumatol, Bangkok, Thailand

[11] Chulalongkorn Univ, Fac Med, Dept Med, Div Allergy & Clin Immunol,Skin & Allergy Res Uni, Bangkok, Thailand

[12] Chulalongkorn Univ, Fac Med, Dept Med, Div Dermatol,Skin & Allergy Res Unit, Bangkok, Thailand

[13] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Dermatol, Bangkok, Thailand

[14] Chiang Mai Univ, Dept Internal Med, Dermatol Div, Chiang Mai, Thailand

[15] Mahidol Univ, Ramathibodi Hosp, Dept Community Med, Bangkok, Thailand

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2018年 / 2018卷

关键词：

STEVENS-JOHNSON-SYNDROME; ADVERSE DRUG-REACTIONS; TOXIC EPIDERMAL NECROLYSIS; INDUCED HYPERSENSITIVITY REACTIONS; DRESS SYNDROME; HLA-B-ASTERISK-1502; ALLELE; SYSTEMIC SYMPTOMS; RISK-FACTOR; METAANALYSIS; POPULATION;

D O I：

10.1155/2018/2780272

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The HLA-B * 15:02 allele has been reported to have a strong association with carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in Thai patients. The HLA-B alleles associated with carbamazepine-induced maculopapular exanthema (MPE) and the drug reaction with eosinophilia and systemic symptoms (DRESS) among the Thai population have never been reported. The aim of the present study was to carry out an analysis of the involvement of HLA-B alleles in carbamazepine-induced cutaneous adverse drug reactions (cADRs) in the Thai population. A case-control study was performed by genotyping the HLA-B alleles of Thai carbamazepine-induced hypersensitivity reaction patients (17 MPE, 16 SJS/TEN, and 5 DRESS) and 271 carbamazepine-tolerant controls. We also recruited 470 healthy Thai candidate subjects who had not taken carbamazepine. HLA-B*15:02 showed a significant association with carbamazepine-induced MPE (P = 0.0022, odds ratio (OR) (95% confidence interval [CI]) = 7.27 (2.04-25.97)) and carbamazepine-induced SJS/TEN (P = 4 46 x 10(-13); OR (95% CI) = 70.91(19.67-255.65)) when compared with carbamazepine-tolerant controls. Carbamazepine-induced SJS/TEN also showed an association with HLA-B* 15:21 allele (P = 0 013; OR (95% CI) = 9.54 (1.61-56.57)) when compared with carbamazepine-tolerant controls. HLA-B* 58: 01 allele was significantly related to carbamazepine-induced MPE (P = 0 007; OR (95% CI) = 4.73 (1.53-14.66)) and DRESS (P = 0 0315; OR (95% CI) = 7.55 (1.20-47.58)) when compared with carbamazepine-tolerant controls. These alleles may serve as markers to predict carbamazepine-induced cADRs in the Thai population.

引用

页数：11

共 33 条

[1] DRESS Syndrome or Hematologic Malignancy? A Case Report of a 4-Year-Old Boy [J].