Selected genetic polymorphisms and plasma coagulation factor VII changes with exercise training

被引:6
作者
Ghiu, IA
Ferrell, RE
Kulaputana, O
Phares, DA
Hagberg, JM [1 ]
机构
[1] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA
[2] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA
关键词
plasma lipoprotein lipids; haplotype; genotype;
D O I
10.1152/japplphysiol.00877.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We assessed the effects of coagulation factor VII (FVII) gene polymorphisms, lipid-related polymorphisms, and exercise training-induced plasma lipoprotein lipid changes on FVII level changes with exercise training in middle- to older-aged men and women. Forty-six healthy sedentary men and women were stabilized on a low-fat diet and then underwent baseline testing, 6 mo of endurance exercise training, and final testing. Plasma FVII-Ag levels decreased with exercise training (106.7+/-1.4 vs. 104.2+/-1.6%, P=0.005). There were no significant differences in FVII-Ag changes with exercise training between -323 (0/10 bp)/-401 (G/T) haplotype or -402 (G/A) genotype groups. FVII-Ag changes with training were not correlated with changes in plasma lipoprotein lipids. In linear regression analyses, FVII-Ag changes with training remained significant after adjusting for training-induced plasma lipoprotein lipid changes (P=0.01). FVII changes with training were associated with apolipoprotein E genotype (P=0.012); this relationship was still evident after adjusting for training-induced plasma lipoprotein lipid changes (P=0.047). FVII changes with training also were significantly associated with human ATPase binding cassette-1 genotype (P=0.018); this relationship persisted after accounting for the effect of the training-induced plasma lipoprotein lipid changes (P=0.045). We conclude that plasma FVII-Ag changes with exercise training are more closely related to selected lipid-related genotypes than FVII gene promoter variants.
引用
收藏
页码:985 / 990
页数:6
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