PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case-control study

被引：2

作者：

Li, Cheng-Lin ^{[1
]}

Zhao, Jian-Qiang ^{[1
]}

Zang, Bao ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Thorac Surg, Affiliated Huaian Peoples Hosp 1, Huaian, Jiangsu, Peoples R China

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2020年 / 34卷 / 09期

关键词：

case-control study; esophageal cancer; PRKAA1; rs13361707; C; T polymorphism; GASTRIC-CANCER; GENE POLYMORPHISMS; RISK; ASSOCIATION; VARIANTS; PATHWAY;

D O I：

10.1002/jcla.23406

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background Several studies probed into the connection between esophageal cancer (EC) risk and PRKAA1 rs13361707 C/T polymorphism, but obtained insignificant findings. Methods In this study, 814 EC cases and 961 controls from Eastern China were recruited to validate the relationship between this polymorphism and EC susceptibility. Results Data suggested rs13361707 C/T polymorphism in PRKAA1 gene was significantly related with a lower risk for EC. Such significant connection was also uncovered in subgroups of males, smokers, drinkers and individuals with age >= 60 years. In addition, this polymorphism was linked with the pathological grading, distant metastasis, and histology of EC. Conclusion In summary, PRKAA1 rs13361707 C/T polymorphism is related to the risk and clinical properties of EC patients in East China.

引用

页数：5

共 23 条

[1] Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC) [J].

Campa, Daniele ;

Claus, Rainer ;

Dostal, Lucie ;

Stein, Angelika ;

Chang-Claude, Jenny ;

Meidtner, Karina ;

Boeing, Heiner ;

Olsen, Anja ;

Tjonneland, Anne ;

Overvad, Kim ;

Rodriguez, Laudina ;

Bonet, Catalina ;

Sanchez, Maria-Jose ;

Amiano, Pilar ;

Huerta, Jose Maria ;

Barricarte, Aurelio ;

Khaw, Kay-Tee ;

Wareham, Nicholas ;

Travis, Ruth C. ;

Allen, Naomi E. ;

Trichopoulou, Antonia ;

Bamia, Christina ;

Benetou, Vassiliki ;

Palli, Domenico ;

Agnoli, Claudia ;

Panico, Salvatore ;

Tumino, Rosario ;

Sacerdote, Carlotta ;

van Kranen, Henk ;

Bueno-de-Mesquita, H. Bas ;

Peeters, Petra H. M. ;

van Gils, Carla H. ;

Lenner, Per ;

Sund, Malin ;

Lund, Eiliv ;

Gram, Inger Torhild ;

Rinaldi, Sabina ;

Chajes, Veronique ;

Romieu, Isabelle ;

Engel, Pierre ;

Boutron-Ruault, Marie Christine ;

Clavel-Chapelon, Francoise ;

Siddiq, Afshan ;

Riboli, Elio ;

Canzian, Federico ;

Kaaks, Rudolf .

BREAST CANCER RESEARCH AND TREATMENT, 2011, 127 (03) :761-767

[2] Cancer Statistics in China, 2015 [J].

Chen, Wanqing ;

Zheng, Rongshou ;

Baade, Peter D. ;

Zhang, Siwei ;

Zeng, Hongmei ;

Bray, Freddie ;

Jemal, Ahmedin ;

Yu, Xue Qin ;

He, Jie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2016, 66 (02) :115-132

[3] Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population [J].

Dai, Ningbin ;

Zheng, Mingfeng ;

Wang, Cheng ;

Ji, Yong ;

Du, Jiangbo ;

Zhu, Chen ;

He, Yisha ;

Zhu, Meng ;

Zhu, Xun ;

Sun, Min ;

Dai, Juncheng ;

Ma, Hongxia ;

Chen, Jingyu ;

Hu, Zhibin ;

Gu, Haiyong ;

Jin, Guangfu ;

Shen, Hongbing .

CANCER SCIENCE, 2014, 105 (06) :731-735

[4] TLR1 and PRKAA1 Gene Polymorphisms in the Development of Atrophic Gastritis and Gastric Cancer [J].

Dargiene, Gintare ;

Streleckiene, Greta ;

Skieceviciene, Jurgita ;

Leja, Marcis ;

Link, Alexander ;

Wex, Thomas ;

Kupcinskas, Limas ;

Malfertheiner, Peter ;

Kupcinskas, Juozas .

JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES, 2018, 27 (04) :363-369

[5] Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries [J].

Domper Arnal, Maria Jose ;

Ferrandez Arenas, Angel ;

Lanas Arbeloa, Angel .

WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (26) :7933-7943

[6] Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population [J].

Dong, Ying ;

Chen, Jing ;

Chen, Zhiqiang ;

Tian, Chaoyong ;

Lu, Huaisheng ;

Ruan, Jigang ;

Yang, Wenjun .

PLOS ONE, 2015, 10 (07)

[7] Genetic Variations of mTORC1 Genes and Risk of Gastric Cancer in an Eastern Chinese Population [J].

He, Jing ;

Wang, Meng-Yun ;

Qiu, Li-Xin ;

Zhu, Mei-Ling ;

Shi, Ting-Yan ;

Zhou, Xiao-Yan ;

Sun, Meng-Hong ;

Yang, Ya-Jun ;

Wang, Jiu-Cun ;

Jin, Li ;

Wang, Ya-Nong ;

Li, Jin ;

Yu, Hong-Ping ;

Wei, Qing-Yi .

MOLECULAR CARCINOGENESIS, 2013, 52 :70-79

[8] Loss-of-function variants in ATM confer risk of gastric cancer [J].

Helgason, Hannes ;

Rafnar, Thorunn ;

Olafsdottir, Halla S. ;

Jonasson, Jon G. ;

Sigurdsson, Asgeir ;

Stacey, Simon N. ;

Jonasdottir, Adalbjorg ;

Tryggvadottir, Laufey ;

Alexiusdottir, Kristin ;

Haraldsson, Asgeir ;

Le Roux, Louise ;

Gudmundsson, Julius ;

Johannsdottir, Hrefna ;

Oddsson, Asmundur ;

Gylfason, Arnaldur ;

Magnusson, Olafur T. ;

Masson, Gisli ;

Jonsson, Thorvaldur ;

Skuladottir, Halla ;

Gudbjartsson, Daniel F. ;

Thorsteinsdottir, Unnur ;

Sulem, Patrick ;

Stefansson, Kari .

NATURE GENETICS, 2015, 47 (08) :906-+

[9] AMP-activated protein kinase induces a p53-dependent metabolic checkpoint [J].

Jones, RG ;

Plas, DR ;

Kubek, S ;

Buzzai, M ;

Mu, J ;

Xu, Y ;

Birnbaum, MJ ;

Thompson, CB .

MOLECULAR CELL, 2005, 18 (03) :283-293

[10] Risk of gastric cancer is associated with PRKAA1 gene polymorphisms in Koreans [J].

Kim, Yong-Dae ;

Yim, Dong-Hyuk ;

Eom, Sang-Yong ;

Moon, Sun In ;

Yun, Hyo-Yung ;

Song, Young-Jin ;

Youn, Sei-Jin ;

Hyun, Taisun ;

Park, Joo-Seung ;

Kim, Byung Sik ;

Lee, Jong-Young ;

Won, Hee Kwan ;

Kim, Heon .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (26) :8592-8598

← 1 2 3 →