Rituximab in ANCA-Associated Vasculitis: Fad or Fact?

被引：9
|
作者：
Fervenza, Fernando C. [1 ]
机构：
[1] Mayo Clin, Coll Med, Div Nephrol & Hypertens, Rochester, MN 55901 USA
来源：
NEPHRON CLINICAL PRACTICE | 2011年 / 118卷 / 02期
关键词：
Rituximab; High-dose glucocorticosteroids; Cyclophosphamide; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CHURG-STRAUSS-SYNDROME; REFRACTORY WEGENERS-GRANULOMATOSIS; B-LYMPHOCYTE DEPLETION; MICROSCOPIC POLYANGIITIS; MAINTENANCE THERAPY; CYCLOPHOSPHAMIDE; RELAPSE; CELLS;
D O I：
10.1159/000321437
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A number of case reports and case series of patients with Wegener's granulomatosis, microscopic polyangiitis and Churg-Strauss syndrome have supported the use of rituximab (RTX) for the treatment of refractory ANCA-associated vasculitis (AAV). Whether B cell depletion with RTX could replace cyclophosphamide as a first-line therapy for patients with severe AAV remains to be proven. Two studies, recently published in the New England Journal of Medicine, have examined the efficacy of RTX in inducing remission in patients with severe AAV. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码：C182 / C188
页数：7
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