Local renin-angiotensin system and the brain-A continuous quest for knowledge

被引：36

作者：

Baltatu, Ovidiu C. ^{[2
,3
]}

Campos, Luciana A. ^{[2
,3
]}

Bader, Michael ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med MDC, D-13125 Berlin, Buch, Germany

[2] Univ Camilo Castelo Branco, Ctr Biomed Engn, BR-12247004 Sao Jose Dos Campos, SP, Brazil

[3] Gr T Popa Univ Med & Pharm, Iasi 700115, Romania

来源：

PEPTIDES | 2011年 / 32卷 / 05期

关键词：

Renin; Angiotensin; BLOOD-PRESSURE VARIABILITY; BRADYKININ-POTENTIATING FACTOR; RENAL SYMPATHETIC DENERVATION; LAMPREY LAMPETRA-FLUVIATILIS; CONVERTING ENZYME-INHIBITION; HEART-RATE-VARIABILITY; TRANSGENIC RATS; RIVER LAMPREY; CYCLOOXYGENASE-2; INHIBITOR; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1016/j.peptides.2011.02.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ancient renin-angiotensin system (RAS) was discovered more than a hundred years ago by identifying the rate-limiting enzyme of the system and its relevance to blood pressure regulation. Forty years ago, Detlev Ganten et al. postulated the existence of a tissue RAS. In these forty years, he kept developing the knowledge of these systems either directly or by training or attracting the interest of many researchers. Through the present review, we try to highlight recent advancements that originated from the postulation of local brain RAS. Although a large amount of knowledge accumulated, this system continues to intrigue and stimulate the interest and imagination of many researchers. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1083 / 1086

页数：4

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