Prolongation and quality of life for HIV-infected adults treated with highly active antiretroviral therapy (HAART): A balancing act

被引:69
作者
Burgoyne, Robert W. [1 ,2 ]
Tan, Darrell H. S. [3 ]
机构
[1] Univ Toronto, Immunodeficiency Clin, Univ Hlth Network, Toronto, ON M5G 2C4, Canada
[2] Univ Toronto, Dept Psychiat, Toronto, ON M5G 2C4, Canada
[3] Univ Toronto, Div Infect Dis, Toronto, ON M5G 2C4, Canada
关键词
AIDS; drug toxicities; QOL;
D O I
10.1093/jac/dkm499
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Advances in highly active antiretroviral therapy (HAART) options for people living with HIV/AIDS have resulted in decreased morbidity and mortality. To some extent, the role of disease progression in eroding quality of life (QOL) erosion in the pre-HAART age is now supplanted by drug toxicities, one of the Achilles' heels of HAART. This article reviews research findings on treatment and QOL outcomes a decade into the HAART era.
引用
收藏
页码:469 / 473
页数:5
相关论文
共 65 条
[1]  
[Anonymous], REP GLOB AIDS EP 200
[2]   A randomized study comparing instruments for measuring health-related quality of life in HIV-infected patients [J].
Badia, X ;
Podzamczer, D ;
Garcia, M ;
López-Lavid, C ;
Consiglio, E .
AIDS, 1999, 13 (13) :1727-1735
[3]   Impact of lipodystrophy on the quality of life of HIV-1-infected patients [J].
Blanch, J ;
Rousaud, A ;
Martínez, E ;
De Lazzari, E ;
Peri, JM ;
Milinkovic, A ;
Perez-Cuevas, TB ;
Blanco, TL ;
Gatell, JM .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2002, 31 (04) :404-407
[4]  
BOEHRINGERINGEL, 2007, APTIVUS TIPRANAVIR C
[5]   The relationship between lipodystrophy-associated body changes and measures of quality of life and mental health for HIV-positive adults [J].
Burgoyne, R ;
Collins, E ;
Wagner, C ;
Abbey, S ;
Halman, M ;
Nur, M ;
Walmsley, S .
QUALITY OF LIFE RESEARCH, 2005, 14 (04) :981-990
[6]   Social support and quality of life over time among adults living with HIV in the HAART era [J].
Burgoyne, R ;
Renwick, R .
SOCIAL SCIENCE & MEDICINE, 2004, 58 (07) :1353-1366
[7]   Long-term quality-of-life outcomes among adults living with HIV in the HAART era: The interplay of changes in clinical factors and symptom profile [J].
Burgoyne, RW ;
Rourke, SB ;
Behrens, DM ;
Salit, IE .
AIDS AND BEHAVIOR, 2004, 8 (02) :151-163
[8]   Quality of life among urban Canadian HIV/AIDS clinic outpatients [J].
Burgoyne, RW ;
Saunders, DS .
INTERNATIONAL JOURNAL OF STD & AIDS, 2001, 12 (08) :505-512
[9]   An objective case definition of lipodystrophy in HIV-infected adults: a case-control study [J].
Carr, A ;
Emery, S ;
Law, I ;
Puls, R ;
Lundgren, JD ;
Powderly, WG ;
Carr, B ;
Cooper, DA ;
Grinspoon, S ;
Ioannidis, J ;
Lewis, R ;
Law, M ;
Lichtenstein, K ;
Murray, J ;
Pizzuti, D ;
Rozenbaum, W ;
Schambelan, M ;
Moore, A ;
Miller, J .
LANCET, 2003, 361 (9359) :726-735
[10]   Health-related quality of life after 1 year of highly active antiretroviral therapy [J].
Carrieri, P ;
Spire, B ;
Duran, S ;
Katlama, C ;
Peyramond, D ;
François, C ;
Chêne, G ;
Lang, JM ;
Moatti, JP ;
Leport, C .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 32 (01) :38-47