Lactones from the Sponge-Derived Fungus Talaromyces rugulosus

被引：37

作者：

Kueppers, Lisa ^{[1
]}

Ebrahim, Weaam ^{[1
,2
]}

El-Neketi, Mona ^{[2
]}

Oezkaya, Ferhat C. ^{[1
]}

Mandi, Attila ^{[3
]}

Kurtan, Tibor ^{[3
]}

Orfali, Raha S. ^{[4
]}

Mueller, Werner E. G. ^{[5
]}

Hartmann, Rudolf ^{[6
]}

Lin, Wenhan ^{[7
]}

Song, Weiguo ^{[8
]}

Liu, Zhen ^{[1
]}

Proksch, Peter ^{[1
]}

机构：

[1] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, D-40225 Dusseldorf, Germany

[2] Mansoura Univ, Dept Pharmacognosy, Fac Pharm, Mansoura 35516, Egypt

[3] Univ Debrecen, Dept Organ Chem, H-4032 Debrecen, Hungary

[4] King Saud Univ, Dept Pharmacognosy, Fac Pharm, Riyadh 11451, Saudi Arabia

[5] Johannes Gutenberg Univ Mainz, Univ Med Johannes Gutenberg, Inst Physiol Chem, D-55128 Mainz, Germany

[6] ForschungszentrumJuelich, Inst Complex Syst Strukturbiochem, D-52428 Julich, Germany

[7] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[8] FukangPharma, North East Dongwaihuan Rd, Shouguang City 262700, Peoples R China

来源：

MARINE DRUGS | 2017年 / 15卷 / 11期

关键词：

Talaromyces rugulosus; lactones; ECD calculation; cytotoxicity; RESORCYLIC ACID LACTONES; ENDOPHYTIC FUNGUS; ABSOLUTE-CONFIGURATION; DERIVATIVES; METABOLITES; MACROLIDES; ASSIGNMENT; XANTHONES;

D O I：

10.3390/md15110359

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The marine-derived fungus Talaromyces rugulosus isolated from the Mediterranean sponge Axinella cannabina and cultured on solid rice medium yielded seventeen lactone derivatives including five butenolides (1-5), seven (3S)-resorcylide derivatives (6-12), two butenolide-resorcylide dimers (13 and 14), and three dihydroisocoumarins (15-17). Among them, fourteen compounds (1-3, 6-16) are new natural products. The structures of the isolated compounds were elucidated by 1D and 2D NMR (Nuclear Magnetic Resonance) spectroscopy as well as by ESI-HRMS (ElectroSpray Ionization-High Resolution Mass Spectrometry). TDDFT-ECD (Time-Dependent Density Functional Theory-Electronic Circular Dichroism) calculations were performed to determine the absolute configurations of chiral compounds. The butenolide-resorcylide dimers talarodilactones A and B (13 and 14) exhibited potent cytotoxicity against the L5178Y murine lymphoma cell line with IC50 values of 3.9 and 1.3 mu M, respectively.

引用

页数：16

共 40 条

[11] Cathepsin B Inhibitory Tetraene Lactones from the Fungus Talaromyces wortmannii [J].