Stem cells in squamous head and neck cancer

被引：54

作者：

Albers, Andreas E. ^{[1
]}

Chen, Chao ^{[2
]}

Koeberle, Beate ^{[3
]}

Qian, Xu

Klussmann, Jens P. ^{[4
]}

Wollenberg, Barbara ^{[5
]}

Kaufmann, Andreas M. ^{[6
]}

机构：

[1] Charite, Hals Nasen Ohrenklin, Dept Otolaryngol & Head & Neck Surg, D-12200 Berlin, Germany

[2] Zhejiang Canc Hosp, Dept Head & Neck Surg, Hangzhou, Zhejiang, Peoples R China

[3] Univ Med Ctr, Inst Toxicol, Mainz, Germany

[4] Univ Hosp Giessen, Dept Otorhinolaryngol Head & Neck Surg, Giessen, Germany

[5] Univ Schleswig Holstein, Dept Otorhinolaryngol Head & Neck Surg, Berlin, Germany

[6] Charite, Clin Gynecol, Gynecol Res Lab, D-12200 Berlin, Germany

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2012年 / 81卷 / 03期

关键词：

Metastasis; Stemness; ALDH1; Sox2; Nanog; Oct3/4; Human papillomavirus; Immunotherapy; Chemoresistance; Radioresistance; Epithelial-mesenchymal transition; EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; ALDEHYDE DEHYDROGENASE 1; HUMAN-PAPILLOMAVIRUS TYPE-16; ACUTE MYELOBLASTIC-LEUKEMIA; RECEPTOR TYROSINE KINASE; MONOCLONAL-ANTIBODY U36; TUMOR-INITIATING CELLS; I DOSE-ESCALATION; CARCINOMA-CELLS;

D O I：

10.1016/j.critrevonc.2011.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The initiation and metastasis of head and neck squamous cell carcinomas (HNSCC) and other cancers have recently been related to the presence of cancer stem cells (CSC). CSC are cancer initiating, sustaining and are mostly quiescent. Specific markers that vary considerably depending on tumor type or tissue of origin characterize putative CSC. Compared to the bulk tumor mass, CSC are less sensitive to chemo-and radiotherapy and may also have low immunogenicity. Therapeutic targeting of CSC may improve clinical outcome of HNSCC which has two distinct etiologies: infection of epithelial stem cells by high-risk types of the human papillomavirus, or long-term tobacco and alcohol abuse. Recent knowledge on the role of CSC in HNSCC is reviewed and where necessary parallels to CSC of other origin are drawn to give a more comprehensive picture. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：224 / 240

页数：17

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