A tripartite asymmetric allylboration-silicon tethered alkene ring closing metathesis in situ ring opening protocol for the regiospecific generation of functionalized (E)-disubstituted homoallylic alcohols

被引：31

作者：

Ahmed, M

Barrett, AGM ^{[1
]}

Beall, JC

Braddock, DC

Flack, K

Gibson, VC

Procopiou, PA

Salter, MM

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

[2] Glaxo Wellcome Res & Dev Ltd, Dept Med Chem, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON | 1999年 / 55卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4020(98)01135-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Molybdenum carbene 6 catalyzed ring closing metathesis of (alkenyl)silyl ethers of homochiral allylic alcohols to afford 1,2-oxasilines which were elaborated in situ to give (E)-4-alkyl-1,2-disubstituted 3-buten-1-ol and (Z)-4-alkyl-4-silyl-1,2-disubstituted 3-buten-1-ol derivatives as single geometric isomers. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3219 / 3232

页数：14

共 29 条

[1]

BARRETT AGM, 1996, J CHEM SOC CHEM COMM, P2229

[2]

BARTLETT PA, 1980, TETRAHEDRON, V36, P3

[3] VINYLSILANE-TERMINATED AND ALKYNYLSILANE-TERMINATED CYCLIZATION REACTIONS [J].