Circadian modulation of membrane properties in slices of rat suprachiasmatic nucleus

被引：73

作者：

de Jeu, M ^{[1
]}

Hermes, N ^{[1
]}

Pennartz, C ^{[1
]}

机构：

[1] Netherlands Inst Brain Res, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands

来源：

NEUROREPORT | 1998年 / 9卷 / 16期

关键词：

amphotericin B; circadian rhythm; gramicidin; membrane potential; membrane resistance; perforated patch; spontaneous firing; suprachiasmatic nucleus;

D O I：

10.1097/00001756-199811160-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

PERFORATED patch clamp recordings of neurons in slices of the suprachiasmatic nucleus (SCN) were made in their subjective day and night phases. The spontaneous firing rate and input resistance were significantly higher during the subjective day as compared to the subjective night. Ln parallel, the membrane potential of neurons recorded at daytime was significantly more depolarized than at nighttime. The day-night differences in membrane potential and input resistance were maintained when spikes and GABAA receptor-mediated transmission were blocked by tetrodotoxin and bicuculline, suggesting a cell-autonomous regulation of the circadian modulation of membrane properties. In conclusion, these findings suggest that at least one hyperpolarizing ionic conductance would be open at night and closed during mid-day, when spontaneous firing reaches peak levels in the SCN. NeuroReport 9: 3725-3729 (C) 1998 Lippincott Williams & Wilkins.

引用

页码：3725 / 3729

页数：5

共 50 条

[41] A computational model of Suprachiasmatic Nucleus (SCN) for circadian rhythm modulation based on ion channel conductance and calcium dynamics
Hyoungkyu Kim
Jaeseung Jeong
[J]. BMC Neuroscience, 11 (Suppl 1)
[42] Effect of suprachiasmatic nucleus lesion on circadian dentin increment in rats
Ohtsuka-Isoya, M
Hayashi, H
Shinoda, H
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2001, 280 (05) : R1364 - R1370
[43] Unimodal circadian rhythm in the suprachiasmatic nucleus of behaviorally splitting mice
Watanabe, T
Yoshimura, T
McMahon, DG
Ebihara, S
[J]. NEUROSCIENCE LETTERS, 2003, 345 (01) : 49 - 52
[44] Circadian expression and specific localization of a sialyltransferase gene in the suprachiasmatic nucleus
Hamada, Yukihiro
Saigoh, Kazumasa
Masumoto, Koh-hei
Nagano, Mamoru
Kusunoki, Susumu
Shigeyoshi, Yasufumi
[J]. NEUROSCIENCE LETTERS, 2013, 535 : 12 - 17
[45] ION CHANNELS CONTROLLING CIRCADIAN RHYTHMS IN SUPRACHIASMATIC NUCLEUS EXCITABILITY
Harvey, Jenna R. M.
Plante, Amber E.
Meredith, Andrea L.
[J]. PHYSIOLOGICAL REVIEWS, 2020, 100 (04) : 1415 - 1454
[46] Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus
Ono, Daisuke
Honma, Ken-ichi
Yanagawa, Yuchio
Yamanaka, Akihiro
Honma, Sato
[J]. JOURNAL OF PHYSIOLOGICAL SCIENCES, 2018, 68 (04) : 333 - 343
[47] Circadian rhythms in mouse suprachiasmatic nucleus explants on multimicroelectrode plates
Herzog, ED
Geusz, ME
Khalsa, SBS
Straume, M
Block, GD
[J]. BRAIN RESEARCH, 1997, 757 (02) : 285 - 290
[48] The suprachiasmatic nucleus and the circadian time-keeping system revisited
van Esseveldt, LKE
Lehman, MN
Boer, GJ
[J]. BRAIN RESEARCH REVIEWS, 2000, 33 (01) : 34 - 77
[49] Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period
Honma, S
Nakamura, W
Shirakawa, T
Honma, K
[J]. NEUROSCIENCE LETTERS, 2004, 358 (03) : 173 - 176
[50] Role of GABA in the regulation of the central circadian clock of the suprachiasmatic nucleus
Daisuke Ono
Ken-ichi Honma
Yuchio Yanagawa
Akihiro Yamanaka
Sato Honma
[J]. The Journal of Physiological Sciences, 2018, 68 : 333 - 343

← 1 2 3 4 5 →