Cladieunicellins A-E, New Eunicellins from an Indonesian Soft Coral Cladiella sp.

被引：26

作者：

Chen, Yung-Husan ^{[5
,6
]}

Tai, Chia-Ying ^{[5
,6
]}

Kuo, Yueh-Hsiung ^{[7
]}

Kao, Chia-Ying ^{[5
,6
]}

Li, Jan-Jung ^{[5
]}

Hwang, Tsong-Long ^{[5
,8
]}

Fang, Lee-Shing ^{[9
]}

Wang, Wei-Hsien ^{[1
,2
,5
]}

Sheu, Jyh-Horng ^{[1
,2
]}

Sung, Ping-Jyun ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Sun Yat Sen Univ, Aisa Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[3] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

[4] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

[5] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[6] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[7] China Med Univ, Coll Pharm, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan

[8] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[9] Cheng Shiu Univ, Dept Sport Hlth & Leisure, Kaohsiung 833, Taiwan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2011年 / 59卷 / 03期

关键词：

cladieunicellin; eunicellin; soft coral; Cladiella; cytotoxicity; superoxide anion; TUMOR-CELL-LINES; DITERPENOIDS; ASSAY;

D O I：

10.1248/cpb.59.353

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new eunicellin-type diterpenoids, cladieunicellins A-E (1-5), were isolated from an Indonesian soft coral identified as Cladiella sp. The structures of diterpenoids 1-5 were established using spectroscopic methods. Eunicellins 2 and 5 were found to be cytotoxic against DLD-1 and HL-60 tumor cells, respectively, and 3 displayed inhibitory effects against superoxide anion generation by human neutrophils.

引用

页码：353 / 358

页数：6

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