Solid-state photocrosslinking of hyaluronan microfibres

被引：21

作者：

Bobula, Tomas ^{[1
]}

Bet'ak, Jiri ^{[1
]}

Buffa, Radovan ^{[1
]}

Moravcova, Martina ^{[1
]}

Klein, Pavel ^{[1
]}

Zidek, Ondrej ^{[1
]}

Chadimova, Veronika ^{[1
]}

Pospisil, Robert ^{[1
]}

Velebny, Vladimir ^{[1
]}

机构：

[1] Contipro Biotech Ltd, Dolni Dobrouc 56102, Czech Republic

来源：

CARBOHYDRATE POLYMERS | 2015年 / 125卷

关键词：

Cinnamic acid; Fibres; Hyaluronan; Photocrosslinking; Wet-spinning; ACID; DERIVATIVES;

D O I：

10.1016/j.carbpol.2015.02.027

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Hyaluronan (HA) was chemically modified to a photocurable derivative by the acylation with a mixed anhydride of trans-cinnamic acid and characterized by UV, IR and 2D NMR spectroscopy. Photocurable HA was processed to a microfibrous structure by wet-spinning technology. Water solubility of otherwise water-soluble HA microfibres was reduced significantly by the solid-state photocrosslinking. We also investigated that the nature of polymer structure had a great impact to a final crosslink ratio. The analysis of the mechanical properties showed higher ultimate tensile strength and increased rigidity of the photocrosslinked fibres in comparison to the untreated ones. Moreover all tested materials are regarded as biocompatible according to the tests of cell viability, phototoxicity and enzymatic degradability, which make them suitable candidates for numerous biomedical applications. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：153 / 160

页数：8

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