A two-front nutritional environment fuels colorectal cancer: perspectives for dietary intervention

被引：12
作者：
Alderweireldt, Elien [1 ]
Grootaert, Charlotte [1 ]
De Wever, Olivier [2 ]
Van Camp, John [1 ]
机构：
[1] Univ Ghent, Fac Biosci Engn, Lab Food Chem & Human Nutr, Ghent, Belgium
[2] Univ Ghent, Fac Med & Hlth Sci, Lab Expt Canc Res, Ghent, Belgium
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2022年 / 33卷 / 02期
关键词：
HIGH-FAT DIET; STEM-CELLS; TUMOR MICROENVIRONMENT; SERINE BIOSYNTHESIS; REDOX HOMEOSTASIS; ACID-METABOLISM; PROTEIN-KINASE; BUTYRATE; METASTASIS; MICROBIOTA;
D O I：
10.1016/j.tem.2021.11.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Colorectal cancer (CRC) develops and progresses in a nutritional environment comprising a continuously changing luminal cocktail of external dietary and microbial factors on the apical side, and a dynamic host-related pool of systemic factors on the serosal side. In this review, we highlight how this two-front environment influences the bioenergetic status of colonocytes throughout CRC development from (cancer) stem cells to cancer cells in nutrient-rich and nutrient-poor conditions, and eventually to metastatic cells, which, upon entry to the circulation and during metastatic seeding, are forced to metabolically adapt. Furthermore, given the influence of diet on the two-front nutritional environment, we discuss dietary strategies that target the specific metabolic preferences of these cells, with a possible impact on colon cancer cell bioenergetics and CRC outcome.
引用
收藏
页码：105 / 119
页数：15
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