Computational image reconstruction for multi-frequency diffuse optical tomography

Diffuse optical tomography (DOT) is promising to investigate functional and structural information in biological tissue by involving the forward problem and inverse solution. The work within this study develops an image reconstruction algorithm based on frequency-domain DOT using multi-frequency. In the forward problem, numerical simulation performs a diffusion equation to compute the light radiance distribution inside the model geometry with the assumed light intensity and optical properties. While in inverse solution, the absorption and reduced scattering coefficients are reconstructed utilizing light boundary data. To test the algorithm, several simulation cases, such as different contrast ratios between background and inclusion, inclusion size, as well as single and multi-frequency using one to three frequencies each and simultaneously are implemented. For verifying the image reconstruction results of multi-frequency, an objective numerical assessment, namely contrast and size detail is applied with a threshold value to specify the visible inclusion inside the geometry. Reconstructed images indicate that the effectivity of two frequencies in multi-frequency with 100 and 150 MHz has similar results as in single-frequency with 200 MHz. Therefore, the more number of frequencies may not enhance the contrast and image quality. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).