Atrial fibrillation in heart failure with preserved ejection fraction: Insights into mechanisms and therapeutics

被引：53

作者：

Patel, Ravi B. ^{[1
,2
]}

Vaduganathan, Muthiah ^{[1
,2
]}

Shah, Sanjiv J. ^{[3
]}

Butler, Javed ^{[4
]}

机构：

[1] Brigham & Womens Heart &Vasc Ctr, 70 Francis St, Boston, MA 02215 USA

[2] Harvard Med Sch, 70 Francis St, Boston, MA 02215 USA

[3] Northwestern Univ, Dept Med, Div Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA

[4] SUNY Stony Brook, Div Cardiol, Stony Brook, NY 11794 USA

来源：

PHARMACOLOGY & THERAPEUTICS | 2017年 / 176卷

基金：

美国国家卫生研究院;

关键词：

Atrial fibrillation; Heart failure; Mechanisms; Therapeutics; LEFT-VENTRICULAR DYSFUNCTION; RHYTHM-CONTROL; CONTRACTILE DYSFUNCTION; SYSTOLIC DYSFUNCTION; FOLLOW-UP; DOGS; RISK; PREVENTION; SUBSTRATE; MORTALITY;

D O I：

10.1016/j.pharmthera.2016.10.019

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Atrial fibrillation (AF) and heart failure (HF) often coexist, and the outcomes of patients who have both AF and HF are considerably worse than those with either condition in isolation. Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical entity and accounts for approximately one-half of current HF. At least one-third of patients with HFpEF are burdened by comorbid AF. The current understanding of the relationship between AF and HFpEF is limited, but the clinical implications are potentially important. In this review, we explore 1) the pathogenesis that drives AF and HFpEF to coexist; 2) pharmacologic therapies that may attenuate the impact of AF in HFpEF; and 3) future directions in the management of this complex syndrome. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：32 / 39

页数：8

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