Gypenosides inhibited invasion and migration of human tongue cancer SCC4 cells through down-regulation of NFκB and matrix metalloproteinase-9

被引：0

作者：

Lu, Kung-Wen ^{[2
]}

Tsai, Ming-Li ^{[2
]}

Chen, Jung-Chou ^{[2
]}

Hsu, Shu-C Hun ^{[3
]}

Hsia, Te-Chun ^{[6
]}

Lin, Meng-Wei ^{[1
]}

Huang, An-Cheng ^{[7
]}

Chang, Yung-Hsien ^{[4
]}

Ip, Siu-Wan ^{[5
]}

Lu, Hsu-Feng ^{[8
]}

Chung, Jing-Gung ^{[1
,9
]}

机构：

[1] China Med Univ, Dept Biol Sci & Technol, Taichung 404, Taiwan

[2] China Med Univ, Chinese Med Res Inst, Taichung 404, Taiwan

[3] China Med Univ, Grad Inst Chinese Pharmaceut Sci, Taichung 404, Taiwan

[4] China Med Univ, Grad Inst Integrat Chinese & Western Med, Taichung 404, Taiwan

[5] China Med Univ, Dept Nutr, Taichung 404, Taiwan

[6] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan

[7] Han Ming Hosp, Dept Pharm, Changhua, Taiwan

[8] Cheng Hsin Rehabil Med Ctr, Dept Clin Pathol, Taipei, Taiwan

[9] Asia Univ, Dept Biotechnol, Taichung, Taiwan

来源：

ANTICANCER RESEARCH | 2008年 / 28卷 / 2A期

关键词：

gypenosides; cell invasion and migration; NF kappa B; MMP-2; MMP-9;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gypenosides (Gyp), components of Gynostemma pentaphyllum Makino, were found to induce suppression of human tongue squamous cell carcinoma SCC4 cell growth and induce apoptosis in response to overexpression of reactive oxygen species, calcium (Ca+2) and to decrease mitochondrial membrane potential in vitro. In this study, the effect of Gyp on cell migration and invasion of human tongue SCC4 cells was examined. SCC4 cells treated in vitro with Gyp migrated and invaded less than cells treated with phosphate-buffered saline (PBS) as a control. Gyp inhibited migration and invasion by down-regulating the production of RAS, NFKB, COX2, ERK1/2 and MMP-9 relative to PBS only. These results show that Gyp inhibits invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis.

引用

页码：1093 / 1099

页数：7

共 25 条

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