Update on animal models developed for analyses of estrogen receptor biological activity

被引：63

作者：

Korach, KS ^{[1
]}

Emmen, JMA ^{[1
]}

Walker, VR ^{[1
]}

Hewitt, SC ^{[1
]}

Yates, M ^{[1
]}

Hall, JM ^{[1
]}

Swope, DL ^{[1
]}

Harrell, JC ^{[1
]}

Couse, JF ^{[1
]}

机构：

[1] NIEHS, Reprod & Dev Toxicol Lab, Receptor Biol Sect, NIH, Res Triangle Pk, NC 27709 USA

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2003年 / 86卷 / 3-5期

关键词：

estrogen receptor; knock-out mice; phenotypes; reproductive tract;

D O I：

10.1016/S0960-0760(03)00348-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeted disruption of the different ER genes has generated experimental animal models that are very useful in evaluating the distinct and cooperative roles of the two estrogen receptors, ERalpha and ERbeta, in reproductive but also non-reproductive tissues of both sexes. Phenotypic analysis has provided definitive experimental findings for estrogen receptor mediated physiological actions, involving ERalpha in uterine, mammary gland and neuroendocrine sites. ERbeta is involved most dramatically in the ovary as is ERalpha. More detailed studies in combination with tissue specific or inducible ER knock outs will be important for future research. (C) 2003 Published by Elsevier Ltd.

引用

页码：387 / 391

页数：5

共 39 条

[1] Mammary Gland Development and Tumorigenesis in Estrogen Receptor Knockout Mice [J].

Bocchinfuso, Wayne P. ;

Korach, Kenneth S. .

JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, 1997, 2 (04) :323-334

[2] Induction of mammary gland development in estrogen receptor-α knockout mice [J].

Bocchinfuso, WP ;

Lindzey, JK ;

Hewitt, SC ;

Clark, JA ;

Myers, PH ;

Cooper, R ;

Korach, KS .

ENDOCRINOLOGY, 2000, 141 (08) :2982-2994

[3] Prolactin controls mammary gland development via direct and indirect mechanisms [J].

Brisken, C ;

Kaur, S ;

Chavarria, TE ;

Binart, N ;

Sutherland, RL ;

Weinberg, RA ;

Kelly, PA ;

Ormandy, CJ .

DEVELOPMENTAL BIOLOGY, 1999, 210 (01) :96-106

[4] Estrogen regulates development of the somatic cell phenotype in the eutherian ovary [J].

Britt, KL ;

Kerr, J ;

O'Donnell, L ;

Jones, MEE ;

Drummond, AE ;

Davis, SR ;

Simpson, ER ;

Findlay, JK .

FASEB JOURNAL, 2002, 16 (11) :1389-1397

[5] An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene [J].

Britt, KL ;

Drummond, AE ;

Cox, VA ;

Dyson, M ;

Wreford, NG ;

Jones, MEE ;

Simpson, ER ;

Findlay, JK .

ENDOCRINOLOGY, 2000, 141 (07) :2614-2623

[6] Postnatal sex reversal of the ovaries in mice lacking estrogen receptors α and β [J].

Couse, JF ;

Hewitt, SC ;

Bunch, DO ;

Sar, M ;

Walker, VR ;

Davis, BJ ;

Korach, KS .

SCIENCE, 1999, 286 (5448) :2328-2331

[7] Tissue distribution and quantitative analysis of estrogen receptor-alpha (ER alpha) and estrogen receptor-beta (ER beta) messenger ribonucleic acid in the wild-type and ER alpha-knockout mouse [J].

Couse, JF ;

Lindzey, J ;

Grandien, K ;

Gustafsson, JA ;

Korach, KS .

ENDOCRINOLOGY, 1997, 138 (11) :4613-4621

[8] ANALYSIS OF TRANSCRIPTION AND ESTROGEN INSENSITIVITY IN THE FEMALE MOUSE AFTER TARGETED DISRUPTION OF THE ESTROGEN-RECEPTOR GENE [J].

COUSE, JF ;

CURTIS, SW ;

WASHBURN, TF ;

LINDZEY, J ;

GOLDING, TS ;

LUBAHN, DB ;

SMITHIES, O ;

KORACH, KS .

MOLECULAR ENDOCRINOLOGY, 1995, 9 (11) :1441-1454

[9] Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-α knockout mouse [J].

Couse, JF ;

Bunch, DO ;

Lindzey, J ;

Schomberg, DW ;

Korach, KS .

ENDOCRINOLOGY, 1999, 140 (12) :5855-5865

[10] Estrogen receptor null mice: What have we learned and where will they lead us? [J].

Couse, JF ;

Korach, KS .

ENDOCRINE REVIEWS, 1999, 20 (03) :358-417

← 1 2 3 4 →