Effects of Vitamin D on the Renin-Angiotensin System and Acute Childhood Pneumonia

被引：3

作者：

Zovi, Andrea ^{[1
]}

Ferrara, Francesco ^{[2
]}

Pasquinucci, Roberta ^{[2
]}

Nava, Livia ^{[3
]}

Vitiello, Antonio ^{[1
]}

Arrigoni, Roberto ^{[4
]}

Ballini, Andrea ^{[5
]}

Cantore, Stefania ^{[6
]}

Palmirotta, Raffele ^{[7
]}

Di Domenico, Marina ^{[5
]}

Santacroce, Luigi ^{[7
]}

Boccellino, Mariarosaria ^{[5
]}

机构：

[1] Minist Hlth, Viale Giorgio Ribotta 5, I-00144 Rome, Italy

[2] Asl Napoli 3 Sud, Pharmaceut Dept, Amicizia St 22, I-80035 Naples, Italy

[3] Asl Napoli 2 Nord, Pharmaceut Dept, I-80027 Naples, Italy

[4] CNR Inst Biomembranes Bioenerget & Mol Biotechnol, I-70124 Bari, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80100 Naples, Italy

[6] Reg Dent Community Serv Sorriso & Benessere Ric &, I-70129 Bari, Italy

[7] Univ Bari Aldo Moro, Sch Med, Interdisciplinary Dept Med, I-70129 Bari, Italy

来源：

ANTIBIOTICS-BASEL | 2022年 / 11卷 / 11期

关键词：

vitamin D; renin-angiotensin system; infectious disease; antibiotics; pharmacology; pneumonia; 1,25-DIHYDROXYVITAMIN D-3; 25-HYDROXYVITAMIN D; CALCIUM;

D O I：

10.3390/antibiotics11111545

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Vitamin D promotes kidney calcium reabsorption and regulates calcium and phosphate metabolism, as well as the intestinal absorption of calcium and phosphorus and bone mineralization events. Vitamin D is also known for its immunomodulatory properties. It has been shown in the literature that the active form of vitamin D, 1,25-dihydroxyvitamin D, performs multiple functions in the adaptive and innate immune system, as well as acting on the endothelial membrane. Recent evidence shows that vitamin D is a negative endocrine modulator of the renin-angiotensin system (RAS), with protection from diseases leading to lung damage, such as pneumonia caused by various pathogens. Vitamin D support associated with the use of antibiotics could be crucial to counteract these infectious diseases.

引用

页数：8

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