Cephalometric Predictors of Clinical Severity in Treacher Collins Syndrome

被引:15
作者
Esenlik, Elcin
Plana, Natalie M.
Grayson, Barry H.
Flores, Roberto L. [1 ]
机构
[1] NYU, Langone Med Ctr, Hansjorg Wyss Dept Plast Surg, 303 East 33rd St, New York, NY 10016 USA
关键词
MANDIBULOFACIAL DYSOSTOSIS; HYPOPLASIA EXISTS; RECONSTRUCTION; CLASSIFICATION; SYSTEM; RANGE;
D O I
10.1097/PRS.0000000000003853
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The aim of this study was to identify cephalometric measurements associated with clinical severity in patients with Treacher Collins syndrome. Methods: A retrospective single-institution review of patients with Treacher Collins syndrome was conducted. Preoperative cephalograms and computed tomographic scans (n = 30) were evaluated. Fifty cephalometric measurements were compared to age-specific normative data using analysis of variance. These cephalometric measurements and the patient's Pruzansky classification were correlated to clinical severity using Spearman analysis. Clinical severity was defined as severe (required tracheostomy), moderate (obstructive sleep apnea, oral cleft, or gastrostomy-tube), or mild (absence of listed comorbidities). Cephalometric measurements with a strong correlation (r > 0.60) were identified as predictors of clinical severity. Results: Cephalograms of the study population contained 30 measurements that were found to be significantly different from normative data (p < 0.01). These measurements were related largely to maxillary/mandibular projection, maxillary/mandibular plane angle, mandibular morphology, facial height, facial convexity, and mandible/throat position. Ten of these 30 statistically significant measurements in addition to Pruzansky classification were found to be strongly correlated (r > 0.60) to clinical severity. These measurements include the following: mandibular projection/position (sella-nasion-pogonion, r = -0.64; hyoid-menton, r = -0.62); posterior facial height (posterior facial height/anterior facial height, r = 0.60; condyle-gonion, r = -0.66); maxillary/mandibular plane angle (sella-nasion-mandibular plane, r = 0.62; Frankfort horizontal-mandibular plane, r = 0.61; sella-nasion-palatal plane, r = 0.69; sella-nasion-symphysis, r = -0.69); and Pruzansky classification (r = 0.82). Conclusion: Specific cephalometric measurements of increased mandibular retrognathia, decreased posterior facial height, more obtuse maxillary/mandibular plane angle and more obtuse symphysis notch angle are strongly correlated to increased clinical severity in patients with Treacher Collins syndrome.
引用
收藏
页码:1240 / 1249
页数:10
相关论文
共 26 条
[1]  
[Anonymous], BOLTON STANDARDS OF
[2]   Comparison between conventional and cone-beam computed tomography-generated cephalograms [J].
Cattaneo, Paolo M. ;
Bloch, Christian Borgkvist ;
Calmar, Dorte ;
Hjortshoj, Mette ;
Melsen, Birte .
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2008, 134 (06) :798-802
[3]  
Chang Christopher C, 2012, Semin Plast Surg, V26, P83, DOI 10.1055/s-0032-1320066
[4]   A Cephalometric Analysis of Maxillary and Mandibular Parameters in Treacher Collins Syndrome [J].
Chong, David K. ;
Murray, Dylan J. ;
Britto, Jonathan A. ;
Tompson, Brian ;
Forrest, Christopher R. ;
Phillips, John H. .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2008, 121 (03) :77E-84E
[5]  
Gorlin RJ, 2001, Syndromes of the head and neck
[6]   THE MANDIBLE IN MANDIBULOFACIAL DYSOSTOSIS - A CEPHALOMETRIC STUDY [J].
GRAYSON, BH ;
BOOKSTEIN, FL ;
MCCARTHY, JG .
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 1986, 89 (05) :393-398
[7]   New grading system for patients with Treacher Collins syndrome [J].
Hayashi, Toshihiko ;
Sasaki, Satoru ;
Oyama, Akihiko ;
Kawashima, Kunihiro ;
Horiuchi, Katsumi ;
William, Mol ;
Yamamoto, Yuhei .
JOURNAL OF CRANIOFACIAL SURGERY, 2007, 18 (01) :113-119
[8]   Cephalometric Assessment of Craniofacial Morphology in Patients With Treacher Collins Syndrome [J].
Kapadia, Hitesh ;
Shetye, Pradip R. ;
Grayson, Barry H. ;
McCarthy, Joseph G. .
JOURNAL OF CRANIOFACIAL SURGERY, 2013, 24 (04) :1141-1145
[9]   Reduced Three-Dimensional Airway Volume Is a Function of Skeletal Dysmorphology in Treacher Collins Syndrome [J].
Ma, Xiaoyang ;
Forte, Antonio J. ;
Persing, John A. ;
Alonso, Nivaldo ;
Berlin, Nicholas L. ;
Steinbacher, Derek M. .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2015, 135 (02) :382E-392E
[10]   THE SKELETAL ANATOMY OF MANDIBULOFACIAL DYSOSTOSIS (TREACHER COLLINS SYNDROME) [J].
MARSH, JL ;
CELIN, SE ;
VANNIER, MW ;
GADO, M .
PLASTIC AND RECONSTRUCTIVE SURGERY, 1986, 78 (04) :460-468