Synthesis of complexable fluorescent superparamagnetic iron oxide nanoparticles (FL SPIONs) and cell labeling for clinical application

被引：50

作者：

Lee, Jae-Ho ^{[1
]}

Schneider, Benjamin ^{[2
]}

Jordan, Elaine K. ^{[1
]}

Liu, Wei ^{[1
,3
]}

Frank, Joseph A. ^{[1
]}

机构：

[1] NIH, Expt Neuroimaging Sect, Lab Diagnost Radiol Res, Bethesda, MD 20892 USA

[2] Univ Maryland, Dept Chem Engn, College Pk, MD 20742 USA

[3] Philips Res N Amer, Briarcliff Manor, NY 10510 USA

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 13期

关键词：

D O I：

10.1002/adma.200800223

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

we describe a new synthesis route for fluorescent superparamagnetic iron oxide nanoparticles (FL SPIONs) and the self-assembled complex formed using FL SPION and protamine sulfate for cell labeling. This synthesis route involves the conjugation of the FDA-approved dextran-coated ferumoxides with fluorescent dextran. The novel nanostructure of FL SPION is stable in vitro and it complexes with a cationic peptide.

引用

页码：2512 / +

页数：6

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