Advances in High-Field BOLD fMRI

被引：21
作者：
Barth, Markus [1 ,2 ]
Poser, Benedikt A. [1 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, NL-6525 HP Nijmegen, Netherlands
[2] Univ Duisburg Essen, Erwin L Hahn Inst Magnet Resonance Imaging, D-45141 Essen, Germany
[3] Univ Hawaii, Dept Med, John A Burns Sch Med, Honolulu, HI 96785 USA
来源：
MATERIALS | 2011年 / 4卷 / 11期
关键词：
BOLD fMRI; high field; 7; Tesla; BOLD response; 2D EPI; 3D EPI; SPIN-ECHO FMRI; HIGH-RESOLUTION; FUNCTIONAL MRI; PHYSIOLOGICAL NOISE; HUMAN BRAIN; 7; T; GRADIENT-ECHO; B-1; INHOMOGENEITY; BLOOD-VESSELS; SIGNAL;
D O I：
10.3390/ma4111941
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
This review article examines the current state of BOLD fMRI at a high magnetic field strength of 7 Tesla. The following aspects are covered: a short description of the BOLD contrast, spatial and temporal resolution, BOLD sensitivity, localization and spatial specificity, technical challenges as well as an outlook on future developments are given. It is shown that the main technical challenges of performing BOLD fMRI at high magnetic field strengths-namely development of array coils, imaging sequences and parallel imaging reconstruction-have been solved successfully. The combination of these developments has lead to the availability of high-resolution BOLD fMRI protocols that are able to cover the whole brain with a repetition time (TR) shorter than 3 s. The structural information available from these high-resolution fMRI images itself is already very detailed, which helps to co-localize structure and function. Potential future applications include whole-brain connectivity analysis on a laminar resolution and single subject examinations.
引用
收藏
页码：1941 / 1955
页数：15
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