A limited range of vagus nerve stimulation intensities produce motor cortex reorganization when delivered during training

被引:27
作者
Morrison, Robert A. [1 ,2 ]
Danaphongse, Tanya T. [2 ]
Pruitt, David T. [2 ]
Adcock, Katherine S. [1 ,2 ]
Mathew, Jobin K. [2 ]
Abe, Stephanie T. [2 ]
Abdulla, Dina M. [1 ,2 ]
Rennaker, Robert L. [1 ,2 ]
Kilgard, Michael P. [1 ,2 ]
Hays, Seth A. [2 ,3 ]
机构
[1] Univ Texas Dallas, Sch Behav Brain Sci, Richardson, TX 75083 USA
[2] Univ Texas Dallas, Texas Biomed Device Ctr, Richardson, TX 75083 USA
[3] Univ Texas Dallas, Erik Jonsson Sch Engn & Comp Sci, Richardson, TX 75083 USA
基金
美国国家卫生研究院;
关键词
Vagus nerve stimulation; Orofacial activity; Intracortical microstimulation; Cortical reorganization; Motor cortex; ISCHEMIC-STROKE; PLASTICITY; RECOVERY; APHASIA; ORGANIZATION;
D O I
10.1016/j.bbr.2020.112705
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Pairing vagus nerve stimulation (VNS) with rehabilitation has emerged as a potential strategy to improve recovery after neurological injury, an effect ascribed to VNS-dependent enhancement of synaptic plasticity. Previous studies demonstrate that pairing VNS with forelimb training increases forelimb movement representations in motor cortex. However, it is not known whether VNS-dependent enhancement of plasticity is restricted to forelimb training or whether VNS paired with other movements could induce plasticity of other motor representations. We tested the hypothesis that VNS paired with orofacial movements associated with chewing during an unskilled task would drive a specific increase in jaw representation in motor cortex compared to equivalent behavioral experience without VNS. Rats performed a behavioral task in which VNS at a specified intensity between 0 and 1.2 mA was paired with chewing 200 times per day for five days. Intracortical microstimulation (ICMS) was then used to document movement representations in motor cortex. VNS paired with chewing at 0.8 mA significantly increased motor cortex jaw representation compared to equivalent behavioral training without stimulation (Bonferroni-corrected unpaired t-test, p < 0.01). Higher and lower intensities failed to alter cortical plasticity. No changes in other movement representations or total motor cortex area were observed between groups. These results demonstrate that 0.8 mA VNS paired with training drives robust plasticity specific to the paired movement, is not restricted to forelimb representations, and occurs with training on an unskilled task. This suggests that moderate intensity VNS may be a useful adjuvant to enhance plasticity and support benefits of rehabilitative therapies targeting functions beyond upper limb movement.
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页数:7
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