The role of natural killer cells in hematopoietic stem cell transplantation

被引：9
作者：
Tsirigotis, Panagiotis D. [1 ]
Resnick, Igor B. [2 ]
Shapira, Michael Y. [2 ]
机构：
[1] Gen Univ Hosp, Athens, Greece
[2] Hadassah Med Ctr, IL-91120 Jerusalem, Israel
来源：
ANNALS OF MEDICINE | 2012年 / 44卷 / 02期
关键词：
Alloreactivity; autoreactivity; haploidentical stem cell transplantation (haplo-SCT); leukemia; natural killer cells (NK); relapse; tolerance; KIR LIGAND INCOMPATIBILITY; HUMAN NK CELLS; BONE-MARROW-TRANSPLANTATION; ACUTE MYELOID-LEUKEMIA; VERSUS-HOST-DISEASE; MHC CLASS-I; IMMUNOGLOBULIN-LIKE RECEPTORS; PERIPHERAL-BLOOD LYMPHOCYTES; ACUTE MYELOGENOUS LEUKEMIA; EXPRESSING INHIBITORY KIR;
D O I：
10.3109/07853890.2011.554430
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Natural killer (NK) cells are important elements of innate immunity, and a large body of evidence supports the significant role of NK in immune surveillance against infections and tumors. Regulation of cytotoxic activity is mediated through activating and inhibitory receptors expressed on the cell surface. NK cells are key players of allogeneic hematopoietic stem cell transplantation (allo-SCT), and previous studies showed the beneficial effect of NK alloreactivity in prevention of relapse, especially in the setting of haploidentical SCT. Biology of human NK cells is an area of active research. Exploitation of the molecular mechanisms regulating NK maturation, tolerance to self, and NK-mediated cytotoxicity will help in the development of innovative NK cell immunotherapy methods.
引用
收藏
页码：130 / 145
页数：16
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