Six new ergostane-type steroids from king trumpet mushroom (Pleurotus eryngii) and their inhibitory effects on nitric oxide production

被引：28

作者：

Kikuchi, Takashi ^{[1
]}

Maekawa, Yukina ^{[1
]}

Tomio, Arisa ^{[1
]}

Masumoto, Yuki ^{[1
]}

Yamamoto, Taishi ^{[1
]}

In, Yasuko ^{[1
]}

Yamada, Takeshi ^{[1
]}

Tanaka, Reiko ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, 4-20-1 Nasahara, Takatsuki, Osaka 5691094, Japan

来源：

STEROIDS | 2016年 / 115卷

关键词：

Pleurotus eryngii; Steroid; Ergostane; Inhibitory effect; Nitric oxide production; CYTOTOXIC STEROIDS; EDIBLE MUSHROOMS; SOFT CORALS; 9,11-SECOSTEROIDS; STEREOCHEMISTRY; POLYSACCHARIDE; CONSTITUENTS; ERGOSTEROLS; DERIVATIVES; BODIES;

D O I：

10.1016/j.steroids.2016.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new ergostane-type steroids; (22E)-3 beta,5 alpha,6 alpha,11-tetrahydroxy-9(11)-seco-ergosta-7,22-dien-9-one (1), (22E)-8,14-epoxyergosta-6,22-diene-3 beta,5 alpha,9 alpha-triol (2), (22E)-4 alpha,5 alpha-epoxyergosta-7,22-diene-3 beta,6 beta-diol (3), (22E)-3 beta,4 beta,5 alpha-trihydroxyergosta-7,22-dien-6-one (4), (22E)-ergosta-7,22-diene-3 beta,5 beta,6 alpha-triol (5), and (22E)-6 beta-methoxyergosta-7,22-diene-3 beta,5 alpha-diol 3-O-beta-D-glucopyranoside (6) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with fourteen known compounds (7-20). All isolated compounds were evaluated for their inhibitory effects on macrophage activation using a nitric oxide production inhibition assay. (C) 2016 Published by Elsevier Inc.

引用

页码：9 / 17

页数：9

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