Prevalence of REM sleep behavior disorder in multiple system atrophy: a multicenter study and meta-analysis

被引：84

作者：

Palma, Jose-Alberto ^{[1
]}

Fernandez-Cordon, Clara ^{[2
]}

Coon, Elizabeth A. ^{[3
]}

Low, Phillip A. ^{[3
]}

Miglis, Mitchell G. ^{[4
]}

Jaradeh, Safwan ^{[4
]}

Bhaumik, Arijit K. ^{[5
]}

Dayalu, Praveen ^{[5
]}

Urrestarazu, Elena ^{[2
]}

Iriarte, Jorge ^{[2
]}

Biaggioni, Italo ^{[6
]}

Kaufmann, Horacio ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Neurol, Dysauton Ctr, New York, NY 10016 USA

[2] Univ Navarra Clin, Sleep Unit, Clin Neurophysiol Sect, Pamplona, Spain

[3] Mayo Clin, Dept Neurol, Rochester, MN USA

[4] Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA

[5] Univ Michigan, Dept Neurol, Ann Arbor, MI USA

[6] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37212 USA

来源：

CLINICAL AUTONOMIC RESEARCH | 2015年 / 25卷 / 01期

基金：

美国国家卫生研究院;

关键词：

alpha-Synuclein; Sleep disorders; Parasomnias; Polysomnography; Parkinsonism; NEURODEGENERATIVE DISEASE; PARKINSONS-DISEASE; BRAIN-STEM; MOVEMENT; IMPROVEMENT; FEATURES; STRIDOR;

D O I：

10.1007/s10286-015-0279-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently affecting patients with synucleinopathies, but its exact prevalence in multiple system atrophy (MSA) is unclear. Whether questionnaires alone are sufficient to diagnose RBD is also unknown. We performed a cross-sectional study of patients with probable MSA from six academic centers in the US and Europe. RBD was ascertained clinically and with polysomnography; we also performed a meta-analysis according to PRISMA guidelines for studies published before September 2014 that reported the prevalence of RBD in MSA. A random-effects model was constructed using weighted prevalence proportions. Only articles in English were included. Studies were classified into those that ascertained the presence of RBD in MSA clinically and with polysomnography. Case reports or case series (a parts per thousand currency sign5 patients) were not included. Forty-two patients completed questionnaires and underwent polysomnography. Of those, 32 (76.1 %) had clinically suspected RBD and 34 (81 %) had polysomnography-confirmed RBD. Two patients reported no symptoms of RBD but had polysomnography-confirmed RBD. The primary search strategy yielded 374 articles of which 12 met the inclusion criteria. The summary prevalence of clinically suspected RBD was 73 % (95 % CI, 62-84 %) in a combined sample of 324 MSA patients. The summary prevalence of polysomnography-confirmed RBD was 88 % (95 % CI, 79-94 %) in a combined sample of 217 MSA patients. Polysomnography-confirmed RBD is present in up to 88 % of patients with MSA. RBD was present in some patients that reported no symptoms. More than half of MSA patients report symptoms of RBD before the onset of motor deficits.

引用

页码：69 / 75

页数：7

共 42 条

[1]

[Anonymous], 2014, ESRS SLEEP MED TXB

[2]

[Anonymous], 2005, INT CLASSIFICATION S

[3] Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia [J].

Benarroch, E. E. ;

Schmeichel, A. M. ;

Dugger, B. N. ;

Sandroni, P. ;

Parisi, J. E. ;

Low, P. A. .

NEUROLOGY, 2009, 73 (02) :106-112

[4] Pedunculopontine nucleus Functional organization and clinical implications [J].

Benarroch, Eduardo E. .

NEUROLOGY, 2013, 80 (12) :1148-1155

[5] Depletion of mesopontine cholinergic and sparing of raphe neurons in multiple system atrophy [J].

Benarroch, EE ;

Schmeichel, AM ;

Parisi, JE .

NEUROLOGY, 2002, 59 (06) :944-946

[6] Brainstem in multiple system atrophy: Clinicopathological correlations [J].

Eduardo E. Benarroch .

Cellular and Molecular Neurobiology, 2003, 23 (4-5) :519-526

[7] Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease [J].

Boeve, B. F. ;

Silber, M. H. ;

Saper, C. B. ;

Ferman, T. J. ;

Dickson, D. W. ;

Parisi, J. E. ;

Benarroch, E. E. ;

Ahlskog, J. E. ;

Smith, G. E. ;

Caselli, R. C. ;

Tippman-Peikert, M. ;

Olson, E. J. ;

Lin, S. -C. ;

Young, T. ;

Wszolek, Z. ;

Schenck, C. H. ;

Mahowald, M. W. ;

Castillo, P. R. ;

Del Tredici, K. ;

Braak, H. .

BRAIN, 2007, 130 :2770-2788

[8] Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder [J].

Boeve, B. F. ;

Silber, M. H. ;

Ferman, T. J. ;

Lin, S. C. ;

Benarroch, E. E. ;

Schmeichel, A. M. ;

Ahlskog, J. E. ;

Caselli, R. J. ;

Jacobson, S. ;

Sabbagh, M. ;

Adler, C. ;

Woodruff, B. ;

Beach, T. G. ;

Iranzo, A. ;

Gelpi, E. ;

Santamaria, J. ;

Tolosa, E. ;

Singer, C. ;

Mash, D. C. ;

Luca, C. ;

Arnulf, I. ;

Duyckaerts, C. ;

Schenck, C. H. ;

Mahowald, M. W. ;

Dauvilliers, Y. ;

Graff-Radford, N. R. ;

Wszolek, Z. K. ;

Parisi, J. E. ;

Dugger, B. ;

Murray, M. E. ;

Dickson, D. W. .

SLEEP MEDICINE, 2013, 14 (08) :754-762

[9] Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy [J].

Boeve, BF ;

Silber, MH ;

Ferman, TJ ;

Lucas, JA ;

Parisi, JE .

MOVEMENT DISORDERS, 2001, 16 (04) :622-630

[10] The improvement of movement and speech during rapid eye movement sleep behaviour disorder in multiple system atrophy [J].

De Cock, Valerie Cochen ;

Debs, Rachel ;

Oudiette, Delphine ;

Leu, Smaranda ;

Radji, Fatai ;

Tiberge, Michel ;

Yu, Huan ;

Bayard, Sophie ;

Roze, Emmanuel ;

Vidailhet, Marie ;

Dauvilliers, Yves ;

Rascol, Olivier ;

Arnulf, Isabelle .

BRAIN, 2011, 134 :856-862

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