Lung Cancer Signatures in Plasma Based on Proteome Profiling of Mouse Tumor Models

被引：131

作者：

Taguchi, Ayumu ^{[1
]}

Politi, Katerina ^{[2
]}

Pitteri, Sharon J. ^{[1
]}

Lockwood, William W. ^{[2
]}

Faca, Vitor M. ^{[1
]}

Kelly-Spratt, Karen ^{[1
]}

Wong, Chee-Hong ^{[1
]}

Zhang, Qing ^{[1
]}

Chin, Alice ^{[1
]}

Park, Kwon-Sik ^{[3
]}

Goodman, Gary ^{[1
]}

Gazdar, Adi F. ^{[4
,5
]}

Sage, Julien ^{[3
]}

Dinulescu, Daniela M. ^{[6
]}

Kucherlapati, Raju

DePinho, Ronald A. ^{[7
,8
]}

Kemp, Christopher J. ^{[1
]}

Varmus, Harold E. ^{[2
]}

Hanash, Samir M. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[2] Mem Sloan Kettering Canc Ctr, Program Canc Biol & Genet, New York, NY 10021 USA

[3] Stanford Univ, Dept Pediat, Stanford, CA 94305 USA

[4] Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA

[5] Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

[6] Harvard Univ, Sch Med, Brigham & Womens Hosp, Eugene Braunwald Res Ctr,Dept Pathol, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Genet, Dana Farber Canc Inst, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Med, Belfer Inst Appl Canc Sci,Dept Med Oncol, Boston, MA 02115 USA

来源：

CANCER CELL | 2011年 / 20卷 / 03期

关键词：

EPIDERMAL-GROWTH-FACTOR; OVARIAN-CANCER; CELL-ADHESION; CLINICOPATHOLOGICAL FEATURES; IMPROVE DETECTION; FACTOR RECEPTOR; SERUM-PROTEINS; K-RAS; MICE; ADENOCARCINOMAS;

D O I：

10.1016/j.ccr.2011.08.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the potential of in-depth quantitative proteomics to reveal plasma protein signatures that reflect lung tumor biology. We compared plasma protein profiles of four mouse models of lung cancer with profiles of models of pancreatic, ovarian, colon, prostate, and breast cancer and two models of inflammation. A protein signature for Titf1/Nkx2-1, a known lineage-survival oncogene in lung cancer, was found in plasmas of mouse models of lung adenocarcinoma. An EGFR signature was found in plasma of an EGFR mutant model, and a distinct plasma signature related to neuroendocrine development was uncovered in the small-cell lung cancer model. We demonstrate relevance to human lung cancer of the protein signatures identified on the basis of mouse models.

引用

页码：289 / 299

页数：11

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