机构:
Univ Colorado, Dept Child Neurol, Aurora, CO 80045 USA
Childrens Hosp, Aurora, CO 80045 USA
Mt States Reg Hemophilia & Thrombosis Ctr, Aurora, CO 80045 USA
Univ Colorado, Pediat Stroke Program, Aurora, CO 80045 USAUniv Colorado, Dept Child Neurol, Aurora, CO 80045 USA
Bernard, Timothy J.
[1
,2
,3
,4
]
Goldenberg, Neil A.
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp, Aurora, CO 80045 USA
Mt States Reg Hemophilia & Thrombosis Ctr, Aurora, CO 80045 USA
Univ Colorado, Pediat Stroke Program, Aurora, CO 80045 USAUniv Colorado, Dept Child Neurol, Aurora, CO 80045 USA
Goldenberg, Neil A.
[2
,3
,4
]
机构:
[1] Univ Colorado, Dept Child Neurol, Aurora, CO 80045 USA
[2] Childrens Hosp, Aurora, CO 80045 USA
[3] Mt States Reg Hemophilia & Thrombosis Ctr, Aurora, CO 80045 USA
[4] Univ Colorado, Pediat Stroke Program, Aurora, CO 80045 USA
Arterial ischemic stroke (AIS) is a rare disorder in children. Research suggests that risk factors, outcomes, and presentation are different from those of adult stroke. In particular, prothrombotic abnormalities and large vessel arteriopathies that are nonatherosclerotic seem to play a large role in the pathogenesis of childhood AIS. This review examines the epidemiology and etiologies of neonatal and childhood AIS and provides a detailed discussion of approaches to the clinical characterization, diagnostic evaluation, and management. Long-term outcomes of recurrent AIS and neuromotor, speech, cognitive, and behavioral deficits are considered. Emphasis is on evidence underlying current knowledge and key questions for further investigation.