512-Channel Geometric Droplet-Splitting Microfluidic Device by Injection of Premixed Emulsion for Microsphere Production

被引：6

作者：

Kim, Chul Min ^{[1
]}

Choi, Hye Jin ^{[2
]}

Kim, Gyu Man ^{[2
]}

机构：

[1] Korea Polytech Univ, Dept Mech Engn, Siheung Si 15073, South Korea

[2] Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea

来源：

POLYMERS | 2020年 / 12卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

premixed emulsion; droplet-splitting; microfluidics; microsphere; high throughput; PLGA MICROSPHERES; GENERATION; BREAKUP; CHIP;

D O I：

10.3390/polym12040776

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We present a 512-channel geometric droplet-splitting microfluidic device that involves the injection of a premixed emulsion for microsphere production. The presented microfluidic device was fabricated using conventional photolithography and polydimethylsiloxane casting. The fabricated microfluidic device consisted of 512 channels with 256 T-junctions in the last branch. Five hundred and twelve microdroplets with a narrow size distribution were produced from a single liquid droplet. The diameter and size distribution of prepared micro water droplets were 35.29 mu m and 8.8% at 10 mL/h, respectively. Moreover, we attempted to prepare biocompatible microspheres for demonstrating the presented approach. The diameter and size distribution of the prepared poly (lactic-co-glycolic acid) microspheres were 6.56 mu m and 8.66% at 10 mL/h, respectively. To improve the monodispersity of the microspheres, we designed an additional post array part in the 512-channel geometric droplet-splitting microfluidic device. The monodispersity of the microdroplets prepared with the microfluidic device combined with the post array part exhibited a significant improvement.

引用

页数：12

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