Experimental Neonatal Sepsis Causes Long-Term Cognitive Impairment

被引：26

作者：

Comim, Clarissa M. ^{[1
]}

Bussmann, Regina M. ^{[1
]}

Simao, Silvia R. ^{[1
]}

Ventura, Leticia ^{[1
]}

Freiberger, Viviane ^{[1
]}

Patricio, Janini J. ^{[1
]}

Palmas, Daphne ^{[1
]}

Mendonca, Bruna P. ^{[2
]}

Cassol-, Omar J., Jr. ^{[1
]}

Quevedo, Joao ^{[2
,3
,4
,5
]}

机构：

[1] Univ South Santa Catarina UNISUL, Postgrad Program Hlth Sci, Lab Expt Neurosci, Res Grp Expt Neuropathol, Palhoca, SC, Brazil

[2] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Hlth Sci Unit, Lab Neurosci, Criciuma, SC, Brazil

[3] Univ Texas Hlth Sci Ctr Houston UTHlth, Sch Med, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA

[4] Univ Texas Hlth Sci Ctr Houston UTHlth, Sch Med, Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, Houston, TX USA

[5] Univ Texas Houston, Grad Sch Biomed Sci Houston, Neurosci Grad Program, Houston, TX USA

来源：

MOLECULAR NEUROBIOLOGY | 2016年 / 53卷 / 09期

关键词：

Central nervous system; Neonatal sepsis; Behavior; Mice; CRITICAL ILLNESS; MEMORY FORMATION; PRETERM INFANTS; INFECTION; RISK; RATS; INFLAMMATION; DEPRESSION; MORTALITY; ADMISSION;

D O I：

10.1007/s12035-015-9495-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neonatal sepsis is a major cause of morbidity and mortality in neonatal intensive care units. Treatment with antibiotics reduces mortality and morbidity, but neonatal sepsis remains a serious life-threatening condition. The objective of this study was to evaluate cognitive impairment in adult mice submitted to sepsis in the neonatal period. To this aim, 2-day-old male C57BL/6 mice were submitted to sepsis by injection of 25 mu g of LPS. Sixty days after, the learning and memory were evaluated. It was observed that the mice submitted to neonatal sepsis presented impairment of habituation, aversive, and object recognition memories, and had an increase of immobility time in forced swimming test in adulthood. In conclusion, this study shows that the neonatal sepsis causes long-term brain alterations. These alterations can persist to adulthood in an animal model due to a vulnerability of the developing brain.

引用

页码：5928 / 5934

页数：7

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