Development of CaZn based glassy alloys as potential biodegradable bone graft substitute

被引：30
作者：
Jiao, W. [2 ]
Li, H. F. [1 ]
Zhao, K. [2 ]
Bai, H. Y. [2 ]
Wang, Y. B. [1 ]
Zheng, Y. F. [1 ]
Wang, W. H. [2 ]
机构：
[1] Peking Univ, Dept Adv Mat & Nanotechnol, Coll Engn, Beijing 100871, Peoples R China
[2] Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China
来源：
JOURNAL OF NON-CRYSTALLINE SOLIDS | 2011年 / 357卷 / 22-23期
关键词：
Biodegradable metal; Mechanical properties; Corrosion; Cytocompatibility; Bone graft substitutes; BULK METALLIC GLASSES; IN-VIVO CORROSION; MAGNESIUM ALLOYS; MAGNETIC-SUSCEPTIBILITY; RARE-EARTH; CALCIUM; CELLS; VITRO; STENTS; ZINC;
D O I：
10.1016/j.jnoncrysol.2011.08.003
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
We report the development of a CaZn based bulk glassy alloy (BGA) with combining properties of low Young's modulus, high fracture strength, good corrosion resistance and cytocompatibility, which make it be potential as biodegradable bone graft substitute. Compared to commonly investigated biodegradable metals, the Young's modulus of the BGA is closer to that of cortical bone, and its fracture strength reaches 600 MPa, which is 2 times higher than that of pure magnesium. The magnetic susceptibility of the CaZn based BGA is as low as 22.3 x 10(-6), which is compatible with magnetic resonance imaging (MRI) diagnosis. The BGAs also show slow degradation rate and good cytocompatibility. The new class of biodegradable CaZn based BGAs enriches the family of biomaterials, and the work has implications for developing new biodegradable alloys with active elements. The formation and the origins of excellent properties of the BGA are discussed. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码：3830 / 3840
页数：11
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