Neural network of bipolar disorder: Toward integration of neuroimaging and neurocircuit-based treatment strategies

被引:34
作者
Bi, Bo [1 ]
Che, Dongfang [2 ]
Bai, Yuyin [1 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Clin Psychol, Shenzhen, Peoples R China
[2] Shenzhen Childrens Hosp, Neurosurg Dept, Shenzhen, Peoples R China
关键词
TRANSCRANIAL MAGNETIC STIMULATION; DEFAULT MODE NETWORK; FUNCTIONAL CONNECTIVITY; WORKING-MEMORY; BRAIN NETWORKS; DOUBLE-BLIND; COGNITIVE IMPAIRMENT; EMOTION REGULATION; LITHIUM TREATMENT; MOTOR CORTEX;
D O I
10.1038/s41398-022-01917-x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Bipolar disorder (BD) is a complex psychiatric disorder characterized by dysfunctions in three domains including emotional processing, cognitive processing, and psychomotor dimensions. However, the neural underpinnings underlying these clinical profiles are not well understood. Based on the reported data, we hypothesized that (i) the core neuropathology in BD is damage in fronto-limbic network, which is associated with emotional dysfunction; (ii) changes in intrinsic brain network, such as sensorimotor network, salience network, default-mode network, central executive network are associated with impaired cognition function; and (iii) beyond the dopaminergic-driven basal ganglia-thalamo-cortical motor circuit modulated by other neurotransmitter systems, such as serotonin (subcortical-cortical modulation), the sensorimotor network and related motor function modulated by other non-motor networks such as the default-mode network are involved in psychomotor function. In this review, we propose a neurocircuit-based clinical characteristics and taxonomy to guide the treatment of BD. We draw on findings from neuropsychological and neuroimaging studies in BD and link variations in these clinical profiles to underlying neurocircuit dysfunctions. We consider pharmacological, psychotherapy, and neuromodulatory treatments that could target those specific neurocircuit dysfunctions in BD. Finally, it is suggested that the methods of testing the neurocircuit-based taxonomy and important limitations to this approach should be considered in future.
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页数:12
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共 114 条
[31]   A dual-networks architecture of top-down control [J].
Dosenbach, Nico U. F. ;
Fair, Damien A. ;
Cohen, Alexander L. ;
Schlaggar, Bradley L. ;
Petersen, Steven E. .
TRENDS IN COGNITIVE SCIENCES, 2008, 12 (03) :99-105
[32]   Distinct brain networks for adaptive and stable task control in humans [J].
Dosenbach, Nico U. F. ;
Fair, Damien A. ;
Miezin, Francis M. ;
Cohen, Alexander L. ;
Wenger, Kristin K. ;
Dosenbach, Ronny A. T. ;
Fox, Michael D. ;
Snyder, Abraham Z. ;
Vincent, Justin L. ;
Raichle, Marcus E. ;
Schlaggar, Bradley L. ;
Petersen, Steven E. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (26) :11073-11078
[33]   The Role of Intrinsic Brain Functional Connectivity in Vulnerability and Resilience to Bipolar Disorder [J].
Doucet, Gaelle E. ;
Bassett, Danielle S. ;
Yao, Nailin ;
Glahn, David C. ;
Frangou, Sophia .
AMERICAN JOURNAL OF PSYCHIATRY, 2017, 174 (12) :1214-1222
[34]   Functional Connectivity Between Anterior Insula and Key Nodes of Frontoparietal Executive Control and Salience Networks Distinguish Bipolar Depression From Unipolar Depression and Healthy Control Subjects [J].
Ellard, Kristen K. ;
Zimmerman, Jared P. ;
Kaur, Navneet ;
Van Dijk, Koene R. A. ;
Roffman, Joshua L. ;
Nierenberg, Andrew A. ;
Dougherty, Darin D. ;
Deckersbach, Thilo ;
Camprodon, Joan A. .
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING, 2018, 3 (05) :473-484
[35]   Differences in psychomotor activity in patients suffering from unipolar and bipolar affective disorder in the remitted or mild/moderate depressive state [J].
Faurholt-Jepsen, Maria ;
Brage, Soren ;
Vinberg, Maj ;
Christensen, Ellen Margrethe ;
Knorr, Ulla ;
Jensen, Hans Morch ;
Kessing, Lars Vedel .
JOURNAL OF AFFECTIVE DISORDERS, 2012, 141 (2-3) :457-463
[36]   Cerebral Correlates of Abnormal Emotion Conflict Processing in Euthymic Bipolar Patients: A Functional MRI Study [J].
Favre, Pauline ;
Polosan, Mircea ;
Pichat, Cedric ;
Bougerol, Thierry ;
Baciu, Monica .
PLOS ONE, 2015, 10 (08)
[37]   A negative double-blind controlled trial of sequential bilateral rTMS in the treatment of bipolar depression [J].
Fitzgerald, Paul B. ;
Hoy, Kate E. ;
Elliot, David ;
McQueen, Susan ;
Wambeek, Lenore E. ;
Daskalakis, Zafiris J. .
JOURNAL OF AFFECTIVE DISORDERS, 2016, 198 :158-162
[38]   Frontal lobe and cognitive development [J].
Fuster, JM .
JOURNAL OF NEUROCYTOLOGY, 2002, 31 (3-5) :373-385
[39]   Clinical applications of transcranial magnetic stimulation in bipolar disorder [J].
Gold, Alexandra K. ;
Ornelas, Ana Claudia ;
Cirillo, Patricia ;
Caldieraro, Marco Antonio ;
Nardi, Antonio Egidio ;
Nierenberg, Andrew A. ;
Kinrys, Gustavo .
BRAIN AND BEHAVIOR, 2019, 9 (10)
[40]   Differentiating Unipolar and Bipolar Depression by Alterations in Large-Scale Brain Networks [J].
Goya-Maldonado, Roberto ;
Brodmann, Katja ;
Keil, Maria ;
Trost, Sarah ;
Dechent, Peter ;
Gruber, Oliver .
HUMAN BRAIN MAPPING, 2016, 37 (02) :808-818