Regulation of growth and death in Escherichia coli by toxin-antitoxin systems

被引：300

作者：

Yamaguchi, Yoshihiro ^{[1
]}

Inouye, Masayori ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Biochem, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 11期

基金：

美国国家卫生研究院;

关键词：

MESSENGER-RNA INTERFERASES; PROGRAMMED CELL-DEATH; DNA-DAMAGE; MULTIDRUG TOLERANCE; PROTEIN-SYNTHESIS; GENE-EXPRESSION; F-PLASMID; TRANSLATION ELONGATION; NUCLEOTIDE-SEQUENCE; BIOFILM FORMATION;

D O I：

10.1038/nrmicro2651

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Escherichia coli K-12 contains at least 36 toxin genes, the expression of which causes growth inhibition and eventual death. These toxins are usually co-expressed with their cognate antitoxins in operons called toxin-antitoxin (TA) modules. Under normal growth conditions, toxins and antitoxins form stable complexes. However, stress-induced proteases preferentially eliminate unstable antitoxins, releasing free toxins to inhibit various cellular functions. TA systems have important roles in the physiology of cells in their natural habitats, including functions in biofilm formation and multidrug resistance. In this Review, we describe these TA systems in light of their functions and roles in the regulation of cell growth and death.

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页码：779 / 790

页数：12

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