Identification of the Myelin Oligodendrocyte Glycoprotein as a Cellular Receptor for Rubella Virus

被引：54

作者：

Cong, Haolong ^{[1
,2
]}

Jiang, Yue ^{[1
]}

Tien, Po ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, Ctr Mol Virol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 21期

基金：

中国国家自然科学基金;

关键词：

FUNCTIONAL RECEPTOR; MEMBRANE-FUSION; ENTRY; E1; REPLICATION; EXPRESSION; PROTEINS; TARGET;

D O I：

10.1128/JVI.05398-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rubella virus (RV) is a highly transmissible pathogenic agent that causes the disease rubella. Maternal RV infection during early pregnancy causes the death of the fetus or congenital rubella syndrome in infants. However, the cellular receptor for RV has not yet been identified. In this study, we found that the myelin oligodendrocyte glycoprotein (MOG) specifically bound to the E1 envelope glycoprotein of RV, and an antibody against MOG could block RV infection. Most importantly, we also showed that ectopic expression of MOG on the cell surface of 293T cells rendered this nonpermissive cell line permissive for RV entry and replication. Thus, this study has identified a cellular receptor for RV and suggests that blocking the MOG attachment site of RV may be a strategy for molecular intervention of RV infection.

引用

页码：11038 / 11047

页数：10

共 41 条

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