The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

被引：112

作者：

Kordinas, Vasileios ^{[1
,2
,3
]}

Ioannidis, Anastasios ^{[3
,4
]}

Chatzipanagiotou, Stylianos ^{[3
]}

机构：

[1] St Panteleimon Gen Hosp, Dept Internal Med 3, Nikea Pireaus 18454, Greece

[2] St Panteleimon Gen Hosp, Ctr Diabet, Nikea Pireaus 18454, Greece

[3] Aeginit Hosp, Athens Med Sch, Dept Clin Microbiol & Med Biopathol, Athens 11528, Greece

[4] Univ Peloponnese, Fac Human Movement & Qual Life Sci, Dept Nursing, Sparta 23100, Greece

来源：

GENES | 2016年 / 7卷 / 09期

关键词：

telomerase; telomeres; inflammation; senescence; BLOOD MONONUCLEAR-CELLS; TELOMERASE REVERSE-TRANSCRIPTASE; LOW-GRADE INFLAMMATION; AGE-RELATED DISEASE; NF-KAPPA-B; DNA-DAMAGE-RESPONSE; CELLULAR SENESCENCE; PERIPHERAL-BLOOD; OXIDATIVE STRESS; CARDIOVASCULAR RISK;

D O I：

10.3390/genes7090060

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Telomeres are specialized nucleoprotein structures located at the end of linear chromosomes and telomerase is the enzyme responsible for telomere elongation. Telomerase activity is a key component of many cancer cells responsible for rapid cell division but it has also been found by many laboratories around the world that telomere/telomerase biology is dysfunctional in many other chronic conditions as well. These conditions are characterized by chronic inflammation, a situation mostly overlooked by physicians regarding patient treatment. Among others, these conditions include diabetes, renal failure, chronic obstructive pulmonary disease, etc. Since researchers have in many cases identified the association between telomerase and inflammation but there are still many missing links regarding this correlation, the latest findings about this phenomenon will be discussed by reviewing the literature. Our focus will be describing telomere/telomerase status in chronic diseases under the prism of inflammation, reporting molecular findings where available and proposing possible future approaches.

引用

页数：22

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