Research criteria for the diagnosis of prodromal dementia with Lewy bodies

被引：426

作者：

McKeith, Ian G. ^{[1
]}

Ferman, Tanis J. ^{[2
]}

Thomas, Alan J. ^{[1
]}

Blanc, Frederic ^{[3
]}

Boeve, Bradley F. ^{[4
]}

Fujishiro, Hiroshige ^{[5
]}

Kantarci, Kejal ^{[4
]}

Muscio, Cristina ^{[6
]}

O'Brien, John T.

Postuma, Ronald B. ^{[7
]}

Aarsland, Dag ^{[8
,9
]}

Ballard, Clive ^{[10
]}

Bonanni, Laura ^{[11
]}

Donaghy, Paul ^{[1
]}

Emre, Murat ^{[12
]}

Galvin, James E. ^{[13
]}

Galasko, Douglas ^{[14
]}

Goldman, Jennifer G. ^{[15
]}

Gomperts, Stephen N.

Honig, Lawrence S. ^{[16
]}

Ikeda, Manabu ^{[17
]}

Leverenz, James B. ^{[18
]}

Lewis, Simon J. G.

Marder, Karen S. ^{[16
]}

Masellis, Mario ^{[19
]}

Salmon, David P. ^{[14
]}

Taylor, John Paul ^{[1
]}

Tsuang, Debby W. ^{[20
,21
,22
]}

Walker, Zuzana ^{[23
]}

Tiraboschi, Pietro ^{[6
]}

机构：

[1] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England

[2] Mayo Clin, Jacksonville, FL 32224 USA

[3] Univ Strasbourg, Strasbourg, France

[4] Mayo Clin, Rochester, MN USA

[5] Nagoya Univ, Kawasaki Mem Hosp, Milan, Italy

[6] Ist Neurol Carlo Besta, Milan, Italy

[7] McGill Univ, Montreal, PQ, Canada

[8] Kings Coll London, London, England

[9] Stavanger Univ Hosp, Stavanger, Norway

[10] Univ Exeter, Exeter, Devon, England

[11] Univ G dAnnunzio, Chieti, Italy

[12] Istanbul Fac Med, Istanbul, Turkey

[13] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA

[14] Univ Calif San Diego, San Diego, CA 92103 USA

[15] Feinberg Sch Med, Chicago, IL USA

[16] Columbia Univ, Irving Med Ctr, New York, NY 10027 USA

[17] Osaka Univ, Suita, Osaka, Japan

[18] Cleveland Clin, Ruvo Ctr Brain Hlth, Cleveland, OH 44106 USA

[19] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[20] Univ Toronto, Toronto, ON, Canada

[21] VA Puget Sound, Seattle, WA USA

[22] Univ Washington, Seattle, WA 98195 USA

[23] UCL, London, England

来源：

NEUROLOGY | 2020年 / 94卷 / 17期

关键词：

MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; BODY DISEASE; DELIRIUM; PATHOLOGY; SYMPTOMS; DISORDER; SUBTYPES; HISTORY;

D O I：

10.1212/WNL.0000000000009323

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The prodromal phase of dementia with Lewy bodies (DLB) includes (1) mild cognitive impairment (MCI), (2) delirium-onset, and (3) psychiatric-onset presentations. The purpose of our review is to determine whether there is sufficient information yet available to justify development of diagnostic criteria for each of these. Our goal is to achieve evidence-based recommendations for the recognition of DLB at a predementia, symptomatic stage. We propose operationalized diagnostic criteria for probable and possible mild cognitive impairment with Lewy bodies, which are intended for use in research settings pending validation for use in clinical practice. They are compatible with current criteria for other prodromal neurodegenerative disorders including Alzheimer and Parkinson disease. Although there is still insufficient evidence to propose formal criteria for delirium-onset and psychiatric-onset presentations of DLB, we feel that it is important to characterize them, raising the index of diagnostic suspicion and prioritizing them for further investigation.

引用

页码：743 / 755

页数：13

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