Ubiquitination-mediated autophagy against invading bacteria

被引：39

作者：

Fujita, Naonobu ^{[1
,2
]}

Yoshimori, Tamotsu ^{[1
,2
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Genet, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Frontier Biosci, Lab Intracellular Membrane Dynam, Suita, Osaka 5650871, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 2011年 / 23卷 / 04期

关键词：

MEMBRANE BIOGENESIS; PROTEIN; RECEPTOR; DEGRADATION; LIPIDATION; P62/SQSTM1; MITOPHAGY; CYTOPLASM; SHIGELLA; DELIVERY;

D O I：

10.1016/j.ceb.2011.03.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is primarily a non-selective intracellular bulk degradation process. However, it was recently shown that ubiquitin-positive substrates, such as protein aggregates, mitochondria, peroxisomes, and invading bacteria, are selectively targeted to lysosomes via autophagy. Thus, ubiquitination seems to function as a general tag for selective autophagy in mammalian cells. This review discusses the present model of how autophagy sequesters invading bacteria through ubiquitination.

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收藏

页码：492 / 497

页数：6

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