Targeted Delivery Methods for Anticancer Drugs

被引：82
作者：
Veselov, Valery V. [1 ]
Nosyrev, Alexander E. [1 ]
Jicsinszky, Laszlo [2 ]
Alyautdin, Renad N. [3 ]
Cravotto, Giancarlo [2 ,4 ]
机构：
[1] Sechenov First Moscow State Med Univ, Ctr Bioanalyt Invest & Mol Design, 8 Trubetskaya Ul, Moscow 119991, Russia
[2] Univ Turin, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy
[3] Sechenov First Moscow State Med Univ, Dept Pharmacol, Moscow 119991, Russia
[4] Sechenov First Moscow State Med Univ, World Class Res Ctr Digital Biodesign & Personali, 8 Trubetskaya Ul, Moscow 119991, Russia
来源：
CANCERS | 2022年 / 14卷 / 03期
关键词：
nanocarriers; metal nanoparticles; dendrimers; oligo- and polysaccharides; solid-lipid systems; stimuli-responsive; IRON-OXIDE NANOPARTICLES; BREAST-CANCER CELLS; CALCIUM-PHOSPHATE NANOPARTICLES; ALBUMIN-BASED NANOPARTICLES; CARBON QUANTUM DOTS; IN-VITRO; MESOPOROUS SILICA; GOLD NANOPARTICLES; MAGNETIC NANOPARTICLES; SIRNA DELIVERY;
D O I：
10.3390/cancers14030622
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Simple Summary The current main technological strategies for the delivery of anticancer drugs are discussed herein. This comprehensive review may help researchers design suitable delivery systems. Several drug-delivery systems have been reported on and often successfully applied in cancer therapy. Cell-targeted delivery can reduce the overall toxicity of cytotoxic drugs and increase their effectiveness and selectivity. Besides traditional liposomal and micellar formulations, various nanocarrier systems have recently become the focus of developmental interest. This review discusses the preparation and targeting techniques as well as the properties of several liposome-, micelle-, solid-lipid nanoparticle-, dendrimer-, gold-, and magnetic-nanoparticle-based delivery systems. Approaches for targeted drug delivery and systems for drug release under a range of stimuli are also discussed.
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页数：28
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