The role of alternative splicing in human cancer progression

被引：1

作者：

Ouyang, Jiawei ^{[1
,2
,3
,4
]}

Zhang, Yijie ^{[1
,2
,3
,4
]}

Xiong, Fang ^{[5
]}

Zhang, Shanshan ^{[5
]}

Gong, Zhaojian ^{[6
]}

Yan, Qijia ^{[5
]}

He, Yi ^{[1
,2
,3
]}

Wei, Fang ^{[4
]}

Zhang, Wenling ^{[7
]}

Zhou, Ming ^{[4
]}

Xiang, Bo ^{[4
]}

Wang, Fuyan ^{[4
]}

Li, Xiaoling ^{[4
]}

Li, Yong ^{[8
]}

Li, Guiyuan ^{[4
]}

Zeng, Zhaoyang ^{[1
,2
,3
,4
]}

Guo, Can ^{[4
]}

Xiong, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Cent South Univ, NHC Key Lab Carcinogenesis, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Hunan Key Lab Canc Metab, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China

[3] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Stomatol, Changsha 410013, Hunan, Peoples R China

[6] Cent South Univ, Xiangya Hosp 2, Dept Oral & Maxillofacial Surg, Changsha 410011, Hunan, Peoples R China

[7] Cent South Univ, Xiangya Hosp 3, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Changsha 410013, Hunan, Peoples R China

[8] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Dept Med, Houston, TX 77030 USA

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Alternative splicing; cancer; splicing factors; isoforms; CircRNA; GROWTH-FACTOR RECEPTOR; RNA-SEQ DATA; MESSENGER-RNA; BREAST-CANCER; CYCLIN D1B; BCL-X; PYRUVATE-KINASE; EXON DEFINITION; CELL-GROWTH; SR PROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the translation of a limited number of coding genes into a large number of proteins with different functions. Although, alternative splicing is common in normal cells, it also plays an important role in cancer development. Alteration in splicing mechanisms and even the participation of non-coding RNAs may cause changes in the splicing patterns of cancer-related genes. This article reviews the latest research on alternative splicing in cancer, with a view to presenting new strategies and guiding future studies related to pathological mechanisms associated with cancer.

引用

页码：4642 / 4667

页数：26

共 50 条

[41] Alternative splicing modulates cancer aggressiveness: role in EMT/metastasis and chemoresistance
Debanwita Roy Burman
Shalini Das
Chandrima Das
Rahul Bhattacharya
Molecular Biology Reports, 2021, 48 : 897 - 914
[42] The role of alternative polyadenylation in cancer progression
Jain, Buddhi Prakash
GENE REPORTS, 2018, 12 : 1 - 8
[43] Hallmarks of alternative splicing in cancer
S Oltean
D O Bates
Oncogene, 2014, 33 : 5311 - 5318
[44] miRNA-Based Regulation of Alternative RNA Splicing in Metazoans
Schorr, Anna L.
Mangone, Marco
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (21)
[45] An intricate rewiring of cancer metabolism via alternative splicing
Temaj, Gazmend
Chichiarelli, Silvia
Saha, Sarmistha
Telkoparan-Akillilar, Pelin
Nuhii, Nexhibe
Hadziselimovic, Rifat
Saso, Luciano
BIOCHEMICAL PHARMACOLOGY, 2023, 217
[46] Regulation of alternative splicing of CD44 in cancer
Prochazka, Lubomir
Tesarik, Radek
Turanek, Jaroslav
CELLULAR SIGNALLING, 2014, 26 (10) : 2234 - 2239
[47] A summary of relationships between alternative splicing and breast cancer
Zhang Xiping
Wei Qingshan
Zhao Shuai
Yang Hongjian
Ding Xiaowen
ONCOTARGET, 2017, 8 (31) : 51986 - 51993
[48] Control of human papillomavirus gene expression by alternative splicing
Graham, Sheila V.
Faizo, Arwa Ali A.
VIRUS RESEARCH, 2017, 231 : 83 - 95
[49] Role of alternative splicing of periostin in human bladder carcinogenesis
Kim, Chul Jang
Isono, Takahiro
Tambe, Yukihiro
Chan, Tokuhiro
Okabe, Hidetoshi
Okada, Yusaku
Inoue, Hirokazu
INTERNATIONAL JOURNAL OF ONCOLOGY, 2008, 32 (01) : 161 - 169
[50] Serine/arginine-rich splicing factors: the bridge linking alternative splicing and cancer
Zheng, Xiang
Peng, Qiu
Wang, Lujuan
Zhang, Xuemei
Huang, Lili
Wang, Jia
Qin, Zailong
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (13): : 2442 - 2453

← 1 2 3 4 5 →