The role of alternative splicing in human cancer progression

被引：1

作者：

Ouyang, Jiawei ^{[1
,2
,3
,4
]}

Zhang, Yijie ^{[1
,2
,3
,4
]}

Xiong, Fang ^{[5
]}

Zhang, Shanshan ^{[5
]}

Gong, Zhaojian ^{[6
]}

Yan, Qijia ^{[5
]}

He, Yi ^{[1
,2
,3
]}

Wei, Fang ^{[4
]}

Zhang, Wenling ^{[7
]}

Zhou, Ming ^{[4
]}

Xiang, Bo ^{[4
]}

Wang, Fuyan ^{[4
]}

Li, Xiaoling ^{[4
]}

Li, Yong ^{[8
]}

Li, Guiyuan ^{[4
]}

Zeng, Zhaoyang ^{[1
,2
,3
,4
]}

Guo, Can ^{[4
]}

Xiong, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Cent South Univ, NHC Key Lab Carcinogenesis, Changsha 410013, Hunan, Peoples R China

[2] Cent South Univ, Hunan Key Lab Canc Metab, Hunan Canc Hosp, Changsha 410013, Hunan, Peoples R China

[3] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China

[4] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China

[5] Cent South Univ, Xiangya Hosp, Dept Stomatol, Changsha 410013, Hunan, Peoples R China

[6] Cent South Univ, Xiangya Hosp 2, Dept Oral & Maxillofacial Surg, Changsha 410011, Hunan, Peoples R China

[7] Cent South Univ, Xiangya Hosp 3, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Changsha 410013, Hunan, Peoples R China

[8] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Dept Med, Houston, TX 77030 USA

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2021年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Alternative splicing; cancer; splicing factors; isoforms; CircRNA; GROWTH-FACTOR RECEPTOR; RNA-SEQ DATA; MESSENGER-RNA; BREAST-CANCER; CYCLIN D1B; BCL-X; PYRUVATE-KINASE; EXON DEFINITION; CELL-GROWTH; SR PROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In eukaryotes, alternative splicing refers to a process via which a single precursor RNA (pre-RNA) is transcribed into different mature RNAs. Thus, alternative splicing enables the translation of a limited number of coding genes into a large number of proteins with different functions. Although, alternative splicing is common in normal cells, it also plays an important role in cancer development. Alteration in splicing mechanisms and even the participation of non-coding RNAs may cause changes in the splicing patterns of cancer-related genes. This article reviews the latest research on alternative splicing in cancer, with a view to presenting new strategies and guiding future studies related to pathological mechanisms associated with cancer.

引用

页码：4642 / 4667

页数：26

共 50 条

[21] Expression of transglutaminase-2 isoforms in normal human tissues and cancer cell lines: dysregulation of alternative splicing in cancer
Phatak, V. M.
Croft, S. M.
Setty, S. G. Rameshaiah
Scarpellini, A.
Hughes, D. C.
Rees, R.
McArdle, S.
Verderio, E. A. M.
AMINO ACIDS, 2013, 44 (01) : 33 - 44
[22] Alternative splicing in EMT and TGF-β signaling during cancer progression
Zhang, Ying E.
Stuelten, Christina H.
SEMINARS IN CANCER BIOLOGY, 2024, 101 : 1 - 11
[23] Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
Urbanski, Laura M.
Leclair, Nathan
Anczukow, Olga
WILEY INTERDISCIPLINARY REVIEWS-RNA, 2018, 9 (04)
[24] Alternative splicing of transposable elements in human breast cancer
Nesta, Alex
Veiga, Diogo F. T.
Banchereau, Jacques
Anczukow, Olga
Beck, Christine R.
MOBILE DNA, 2025, 16 (01):
[25] Alternative Splicing as a Target for Cancer Treatment
Martinez-Montiel, Nancy
Rosas-Murrieta, Nora Hilda
Anaya Ruiz, Maricruz
Monjaraz-Guzman, Eduardo
Martinez-Contreras, Rebeca
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (02)
[26] Targeting alternative splicing in cancer immunotherapy
Han, Nan
Liu, Zhaoqi
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2023, 11
[27] Impact of Alternative Splicing on the Human Proteome
Liu, Yansheng
Gonzalez-Porta, Mar
Santos, Sergio
Brazma, Alvis
Marioni, John C.
Aebersold, Ruedi
Venkitaraman, Ashok R.
Wickramasinghe, Vihandha O.
CELL REPORTS, 2017, 20 (05): : 1229 - 1241
[28] Global Signaling Profiling in a Human Model of Tumorigenic Progression Indicates a Role for Alternative RNA Splicing in Cellular Reprogramming
Caruso, Joseph A.
Carruthers, Nicholas J.
Thibodeau, Bryan
Geddes, Timothy J.
Dombkowski, Alan A.
Stemmer, Paul M.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (10)
[29] Splicing factors: Insights into their regulatory network in alternative splicing in cancer
Du, Jun-Xian
Zhu, Gui-Qi
Cai, Jia-Liang
Wang, Biao
Luo, Yi-Hong
Chen, Cong
Cai, Cheng-Zhe
Zhang, Si-Jia
Zhou, Jian
Fan, Jia
Zhu, Wei
Dai, Zhi
CANCER LETTERS, 2021, 501 : 83 - 104
[30] Role of alternative splicing signatures in the prognosis of glioblastoma
Xie, Zu-cheng
Wu, Hua-yu
Dang, Yi-wu
Chen, Gang
CANCER MEDICINE, 2019, 8 (18): : 7623 - 7636

← 1 2 3 4 5 →