Glucocorticoid-Induced Osteoporosis

被引：245

作者：

Buckley, Lenore ^{[1
]}

Humphrey, Mary B. ^{[2
]}

机构：

[1] Yale Sch Med, 300 Cedar St,POB 208831, New Haven, CT 06520 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 379卷 / 26期

关键词：

BONE-MINERAL DENSITY; DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; POSTMENOPAUSAL WOMEN; VERTEBRAL FRACTURES; ORAL CORTICOSTEROIDS; BREAST-CANCER; PREVENTION; RISK; PLACEBO;

D O I：

10.1056/NEJMcp1800214

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

For the past month, a 75-year-old woman with polymyalgia rheumatica has received prednisone at a dose of 20 mg daily. The treatment plan is to try to taper the dose to 5 mg daily within 6 months. Given typical durations of treatment, the expectation is that she will continue to receive prednisone for 2 years. She is otherwise healthy and has no personal or family history of fracture. She does not smoke or drink alcohol. Her height is 168 cm, and she weighs 68 kg. Her serum 25-hydroxyvitamin D level is 30 ng per milliliter (74 nmol per liter). Her bone mineral density T score is -1.2 at the femoral neck. What would you advise to prevent glucocorticoid-induced osteoporosis and fracture?

引用

页码：2547 / 2556

页数：10

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