Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease

被引：21

作者：

Warner, Bryce M. ^{[1
]}

Santry, Lisa A. ^{[2
]}

Leacy, Alexander ^{[2
]}

Chan, Mable ^{[1
]}

Pham, Phuc H. ^{[2
]}

Vendramelli, Robert ^{[1
]}

Pei, Yanlong ^{[2
]}

Tailor, Nikesh ^{[1
]}

Valcourt, Emelissa ^{[1
]}

Leung, Anders ^{[1
]}

He, Shihua ^{[1
]}

Griffin, Bryan D. ^{[1
]}

Audet, Jonathan ^{[1
]}

Willman, Marnie ^{[3
]}

Tierney, Kevin ^{[1
]}

Albietz, Alixandra ^{[1
]}

Frost, Kathy L. ^{[1
]}

Yates, Jacob G. E. ^{[2
]}

Mould, Robert C. ^{[2
]}

Chan, Lily ^{[2
]}

Mehrani, Yeganeh ^{[2
]}

Knapp, Jason P. ^{[2
]}

Minott, Jessica A. ^{[2
]}

Banadyga, Logan ^{[1
]}

Safronetz, David ^{[1
,3
]}

Wood, Heidi ^{[1
]}

Booth, Stephanie ^{[1
]}

Major, Pierre P. ^{[4
]}

Bridle, Byram W. ^{[2
]}

Susta, Leonardo ^{[2
]}

Kobasa, Darwyn ^{[1
,3
]}

Wootton, Sarah K. ^{[2
]}

机构：

[1] Publ Hlth Agcy Canada, Zoonot Dis & Special Pathogens, Winnipeg, MB, Canada

[2] Univ Guelph, Dept Pathobiol, Guelph, ON, Canada

[3] Univ Manitoba, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada

[4] Juravinski Canc Ctr, 699 Concess St, Hamilton, ON L8V 5C2, Canada

来源：

ISCIENCE | 2021年 / 24卷 / 11期

基金：

加拿大自然科学与工程研究理事会;

关键词：

AVIAN INFLUENZA-VIRUSES; SMALL ANIMAL-MODEL; SYRIAN-HAMSTERS; HIGH-TITER; COVID-19; IMMUNIZATION; REQUIREMENT; PRIMATES; ANTIGEN; CELLS;

D O I：

10.1016/j.isci.2021.103219

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newcastle disease virus (NDV) vectors expressing either the full-length SARS-CoV-2 spike protein (NDV-FLS) or a version with a 19 amino acid deletion at the carboxy terminus (NDV-Delta 19S). Hamsters receiving two doses (prime-boost) of NDV-FLS developed a robust SARS-CoV-2-neutralizing antibody response, with elimination of infectious virus in the lungs and minimal lung pathology at five days post-challenge. Single-dose vaccination with NDV-FLS significantly reduced SARS-CoV-2 replication in the lungs but only mildly decreased lung inflammation. NDV-Delta 19S-treated hamsters had a moderate decrease in SARS-CoV-2 titers in lungs and presented with severe microscopic lesions, suggesting that truncation of the spike protein was a less effective strategy. In summary, NDV-vectored vaccines represent a viable option for protection against COVID-19.

引用

页数：28

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