Enhancing extracellular vesicles for therapeutic treatment of arthritic joints

被引：6

作者：

Austin-Williams, Shani ^{[1
]}

Hussain, Mohammed T. ^{[1
]}

Oggero, Silvia ^{[1
]}

Norling, Lucy, V ^{[1
,2
]}

机构：

[1] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1M 6BQ, England

[2] Queen Mary Univ London, Ctr Inflammat & Therapeut Innovat, London, England

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2021年 / 175卷

基金：

欧盟地平线“2020”;

关键词：

Extracellular vesicles; Rheumatoid arthritis; Osteoarthritis; miRNA; Targeting; MESENCHYMAL STEM-CELLS; TOLL-LIKE RECEPTORS; DENDRITIC CELLS; RHEUMATOID-ARTHRITIS; ARTICULAR-CARTILAGE; GENE-EXPRESSION; OSTEOGENIC DIFFERENTIATION; PROTEOMIC ANALYSIS; OXIDATIVE STRESS; HYDROGEL GLUE;

D O I：

10.1016/j.freeradbiomed.2021.08.235

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular vesicles are small membrane-derived packages of information that are released from virtually all cell types. These nano-packages contain regulatory material including proteins, lipids, mRNA and microRNA and are a key mechanism of paracellular communication within a given microenvironment. Encompassed with a lipid bilayer, these organelles have been attributed numerous roles in regulating both physiological and pathological functions. Herein, we describe the role of EVs in the context of Rheumatoid and Osteoarthritis and explore how they could be harnessed to treat inflammatory and degenerative joint conditions. These structures offer a promising therapeutic strategy for treating musculoskeletal diseases due to their bioactive content, stability, small size and intrinsic ability to enter the avascular cartilage, a notoriously challenging tissue to target. We also discuss how EVs can be manipulated to load therapeutic cargo or present additional targeting moieties to enhance their beneficial actions and tissue regenerative properties.

引用

页码：80 / 94

页数：15

共 201 条

[61] Tumour exosome integrins determine organotropic metastasis [J].

Hoshino, Ayuko ;

Costa-Silva, Bruno ;

Shen, Tang-Long ;

Rodrigues, Goncalo ;

Hashimoto, Ayako ;

Mark, Milica Tesic ;

Molina, Henrik ;

Kohsaka, Shinji ;

Di Giannatale, Angela ;

Ceder, Sophia ;

Singh, Swarnima ;

Williams, Caitlin ;

Soplop, Nadine ;

Uryu, Kunihiro ;

Pharmer, Lindsay ;

King, Tari ;

Bojmar, Linda ;

Davies, Alexander E. ;

Ararso, Yonathan ;

Zhang, Tuo ;

Zhang, Haiying ;

Hernandez, Jonathan ;

Weiss, Joshua M. ;

Dumont-Cole, Vanessa D. ;

Kramer, Kimberly ;

Wexler, Leonard H. ;

Narendran, Aru ;

Schwartz, Gary K. ;

Healey, John H. ;

Sandstrom, Per ;

Labori, Knut Jorgen ;

Kure, Elin H. ;

Grandgenett, Paul M. ;

Hollingsworth, Michael A. ;

de Sousa, Maria ;

Kaur, Sukhwinder ;

Jain, Maneesh ;

Mallya, Kavita ;

Batra, Surinder K. ;

Jarnagin, William R. ;

Brady, Mary S. ;

Fodstad, Oystein ;

Muller, Volkmar ;

Pantel, Klaus ;

Minn, Andy J. ;

Bissell, Mina J. ;

Garcia, Benjamin A. ;

Kang, Yibin ;

Rajasekhar, Vinagolu K. ;

Ghajar, Cyrus M. .

NATURE, 2015, 527 (7578) :329-+

[62] Growth factor signalling in osteoarthritis [J].

Huang, Jian ;

Zhao, Lan ;

Chen, Di .

GROWTH FACTORS, 2018, 36 (5-6) :187-195

[63] Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients [J].

Humby, Frances ;

Lewis, Myles ;

Ramamoorthi, Nandhini ;

Hackney, Jason A. ;

Barnes, Michael R. ;

Bombardieri, Michele ;

Setiadi, A. Francesca ;

Kelly, Stephen ;

Bene, Fabiola ;

DiCicco, Maria ;

Riahi, Sudeh ;

Rocher, Vidalba ;

Ng, Nora ;

Lazarou, Ilias ;

Hands, Rebecca ;

van der Heijde, Desiree ;

Landewe, Robert B. M. ;

van der Helm-van Mil, Annette ;

Cauli, Alberto ;

McInnes, Iain ;

Buckley, Christopher Dominic ;

Choy, Ernest H. ;

Taylor, Peter C. ;

Townsend, Michael J. ;

Pitzalis, Costantino .

ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 (06) :761-772

[64] Stabilization of Exosome-targeting Peptides via Engineered Glycosylation [J].

Hung, Michelle E. ;

Leonard, Joshua N. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (13) :8166-8172

[65] SINGLE INTRA-ARTICULAR INJECTION OF TLC599 PROVIDED SUSTAINED PAIN RELIEF THROUGH 24 WEEKS IN PARTICIPANTS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS [J].

Hunter, D. ;

Chang, C. -C. ;

Wei, J. -C. ;

Lin, H. -Y. ;

Brown, C. ;

Shih, S. -F. .

OSTEOARTHRITIS AND CARTILAGE, 2019, 27 :S87-S88

[66] Structural correlates of pain in joints with osteoarthritis [J].

Hunter, D. J. ;

Guermazi, A. ;

Roemer, F. ;

Zhang, Y. ;

Neogi, T. .

OSTEOARTHRITIS AND CARTILAGE, 2013, 21 (09) :1170-1178

[67] Osteoarthritis [J].

Hunter, David J. ;

Bierma-Zeinstra, Sita .

LANCET, 2019, 393 (10182) :1745-1759

[68] Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo [J].

Hyenne, Vincent ;

Ghoroghi, Shima ;

Collot, Mayeul ;

Bons, Joanna ;

Follain, Gautier ;

Harlepp, Sebastien ;

Mary, Benjamin ;

Bauer, Jack ;

Mercier, Luc ;

Busnelli, Ignacio ;

Lefebvre, Olivier ;

Fekonja, Nina ;

Garcia-Leon, Maria J. ;

Machado, Pedro ;

Delalande, Francois ;

Amor Lopez, Ana ;

Garcia Silva, Susana ;

Verweij, Frederik J. ;

van Niel, Guillaume ;

Djouad, Farida ;

Peinado, Hector ;

Carapito, Christine ;

Klymchenko, Andrey S. ;

Goetz, Jacky G. .

DEVELOPMENTAL CELL, 2019, 48 (04) :554-+

[69]

Jay GD, 2000, J RHEUMATOL, V27, P594

[70] Comparison of immunomodulatory properties of exosomes derived from bone marrow mesenchymal stem cells and dental pulp stem cells [J].

Ji, Lujun ;

Bao, Liuliu ;

Gu, Zhifeng ;

Zhou, Qiao ;

Liang, Yi ;

Zheng, Ya ;

Xu, Yang ;

Zhang, Xiang ;

Feng, Xingmei .

IMMUNOLOGIC RESEARCH, 2019, 67 (4-5) :432-442

← 2 3 4 5 6 7 8 9 10 11 →